RT - Journal Article T1 - Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in Mice JF - RUMS_JOURNAL YR - 2004 JO - RUMS_JOURNAL VO - 3 IS - 4 UR - http://journal.rums.ac.ir/article-1-32-en.html SP - 243 EP - 249 K1 - Acute and Chronic Pain K1 - Coriandrum Sativum K1 - Formalin Test K1 - Mice AB -   Effect of Aqueous Extract of the Coriandrum Sativum Seed on the Reduction of Acute and Chronic Pain in M ice     AA. Taherian MD ¹*, A. Rashidy-Pour PhD 2 , AA. Vafaei PhD 3 , M. Jarrahi MSc 4 , H. Miladi-Gorgi MSc 4 , M. Emami-Abarghooii PharmD 4 , H. Sadeghi BSc 5     1- Academic Member, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran   2- Associated Professor, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran   3 – Assistant Professore, Dept. of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan Iran   4- Academic Member, Dept. of Physiology, University of Medical Sciences, Semnan, Iran   5- BSc, Dept of Physiology, Faculty of Medical Sciences, Semnan Iran     Background: Previous investigations have shown that Coriandrum Sativum (CS) extract probably modulates pain in human and animal. The aim of this investigation was assessment of the role of CS on acute and chronic pain by formalin test in mice.   Materials and Methods: In this study, 35 male albino mice in 5 groups (25-30g) were used. CS extract (100, and 200mg/kg), or saline were injected intera-peritoneal (IP) 30 mins before the formalin test. Indices of signs of pain were licking and foot elevation for assessment of acute pain (5 min), and chronic pain (15-40 min) after the injection of formalin 5% (25µl) in the right paw.   Reasults: Results showed that although CS extract has analgesic effect in both doses in acute and chronic pain, (p LA eng UL http://journal.rums.ac.ir/article-1-32-en.html M3 ER -