Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.61186/jrums
fa
jalali
1394
7
1
gregorian
2015
10
1
14
7
online
1
fulltext
fa
فراوانی و عوامل مرتبط با مسمومیّت متادون در کودکان زیر 15 سال مراجعه کننده به اورژانس اطفال بیمارستان علی ابن ابیطالب رفسنجان در سال ۱۳۹۲
Frequency and Related Factors of Methadone Poisoning in Children Aged under 15 Years Attending Children Emergency Center of Rafsanjan Ali-Ebne-Abitaleb Hospital In 2013
اطفال
Pediatrics
پژوهشي
Research
<p class="MsoNormal" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 10.5pt margin-bottom: 0.0001pt text-align: justify line-height: 117% "><!--stripped--> gte vml 1]><v:roundrect
id="_x0000_s1026" style='position:absoluteleft:0text-align:left
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</v:roundrect><!--stripped--><span style="position: absolute z-index: -1 left: 0px margin-left: 6px margin-top: 2px width: 602px height: 542px "><img alt="AWT IMAGE" width="602" height="542" src="file:///C:/DOCUME~1/ADMINI~1/LOCALS~1/Temp/msohtmlclip1/01/clip_image001.gif" v:shapes="_x0000_s1026" ></span><b><span lang="FA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">چکیده</span></b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' "><o:p /></span></p>
<p class="2CxSpFirst" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 10.5pt margin-bottom: 0.0001pt line-height: 117% "><b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">زمینه
و هدف:</span></b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' "> </span><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">افزایش
تجویز متادون در برنامههای ترک مواد مخدر در سالهای اخیر موجب بالارفتن آمار
مسمومیّت تصادفی به آن، به ویژه در کودکان شده است. هدف این مطالعه، تعیین فراوانی
مسمومیّت با متادون و علل احتمالی آن در کودکان زیر ۱۵ سال بود.</span><span lang="X-NONE" dir="LTR" style="font-size: 10pt line-height: 117% "><o:p /></span></p>
<p class="2CxSpMiddle" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 10.5pt margin-bottom: 0.0001pt line-height: 117% "><b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">مواد و روشها:</span></b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' "> در این مطالعه مقطعی، ۹۷ کودک دچار مسمومیّت با متادون
در اورژانس اطفال بیمارستان علی ابن ابیطالب (ع) در سال 1392 بررسی شدند</span><span dir="LTR"></span><span lang="X-NONE" dir="LTR" style="font-size: 10pt line-height: 117% "><span dir="LTR"></span>.</span><span dir="RTL"></span><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' "><span dir="RTL"></span> اطلاعات
مورد نیاز از طریق معاینه پزشکی و مصاحبه جمعآوری و ثبت گردید. دادهها با روشهای
آمار توصیفی و آزمونهای آماری شامل ضریب همبستگی، مجذور کای و اختلاف میانگینها
مورد بررسی قرار گرفتند.</span><span lang="X-NONE" dir="LTR" style="font-size: 10pt line-height: 117% "><o:p /></span></p>
<p class="2CxSpMiddle" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 10.5pt margin-bottom: 0.0001pt line-height: 117% "><a name="OLE_LINK33"></a><a name="OLE_LINK32"><span><b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">یافتهها: </span></b></span></a><span><span><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">از مجموع 97 کودک مسموم، تعداد ۵۷ نفر<b> (</b>76/58%) و
۴۰ نفر (24/41%) به ترتیب پسر و دختر بودند. <a name="OLE_LINK20"></a><a name="OLE_LINK19"></a><a name="OLE_LINK18"><span><span>تعداد ۷ نفر (2/7%)</span></span></a><span> از این کودکان</span>، ۶۷ نفر (1/۶۹%) از پدران
و 16 نفر (5/۱۶%) از مادران آنها اعتیاد داشتند. در 71 مورد (2/73%)، مسمومیّت به
صورت اتفاقی رخ داده بود. میانگین فاصله زمانی مراجعه به اورژانس معادل 24/۲±14/۳
ساعت و میانگین تعداد آمپول نالوکسان مصرفی برابر با 7/۱۲±3/۱۶ آمپول بود. بیشترین
مراجعه در شیفت شب و فصل پاییز وجود داشت. در هنگام مراجعه، ۲۰ نفر (6/۲۰%) دارای
علائم خطر شدید و ۵۳ نفر (6/۵۴%) دارای علائم خطر متوسط و ۲۴ نفر (7/۲۴%) بدون
علامت بودند. میزان بروز مسمومیّت با متادون و شدّت و عوارض آن، ارتباط آماری معنیداری
(0۵/0></span></span></span><span><span><span lang="X-NONE" dir="LTR" style="font-size: 10pt line-height: 117% ">p</span></span></span><span><span><span dir="RTL"></span><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' "><span dir="RTL"></span>) با
اعتیاد، سن و سطح سواد مادر، با اعتیاد و رتبه تولد کودک، وضعیت اقتصادی خانواده،
محل سکونت، فاصله زمانی مراجعه به اورژانس،</span></span></span><span><span><span dir="LTR"></span><span lang="AR-SA" dir="LTR" style="font-size: 10pt line-height: 117% "><span dir="LTR"></span>
</span></span></span><span><span><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">نحوه
نگهداری و حجم متادون مصرفی داشت. <o:p /></span></span></span></p>
<p class="2CxSpLast" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 10.5pt margin-bottom: 0.0001pt line-height: 117% "><span><span><b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">نتیجهگیری:</span></b></span></span><span><span><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' "> فصل، شرایط مادر، اعتیاد و رتبه تولد کودک، وضعیت
اقتصادی خانواده و محل سکونت از مهمترین عوامل در رابطه با مسمومیّت با متادون در
کودکان بود. <o:p /></span></span></span></p>
<span></span><span></span>
<p class="MsoNormalCxSpFirst" dir="RTL" style="margin-top: 0cm margin-right: 2.85pt margin-left: 10.5pt margin-bottom: 0.0001pt text-align: justify line-height: 117% "><b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">واژههای کلیدی</span></b><span lang="AR-SA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">: مسمومیّت، متادون، کودکان، </span><span lang="AR-SA" style="font-size: 6pt line-height: 117% font-family: 'B Nazanin' "><span> </span></span><span lang="FA" style="font-size: 12pt line-height: 117% font-family: 'B Nazanin' ">فراوانی</span><span lang="FA" style="font-size: 6pt line-height: 117% font-family: 'B Nazanin' "><o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Background
and Objective</span></b><span style="font-family: 'Times New Roman', serif ">: </span><span style="font-family: 'Times New Roman', serif ">Increased
methadone <a name="OLE_LINK15"></a><a name="OLE_LINK14"><span>prescription</span></a> in narcotics withdrawal protocols in recent
years resulted in a high number of accidental methadone poisoning, especially
in children. The aim of the study was to determine the frequency of methadone
poisoning and its probable causes in children aged less than 15 years.<o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Materials and Methods: </span></b><span style="font-family: 'Times New Roman', serif ">In
this cross-sectional study, 97 children with methadone poisoning admitted to
emergency medical services of Ali-Ebne-Abitaleb hospital in Rafsanjan were investigated.
Data were collected through medical examination and interview and analyzed by
descriptive and analytical statistical methods including correlation
coefficient, Chi-Square and comparison of means tests.<o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Results:</span></b><span style="font-family: 'Times New Roman', serif "> Out of total 97 </span><span style="font-family: 'Times New Roman', serif ">poisoned children</span><span style="font-family: 'Times New Roman', serif ">, 57 (</span><span style="font-family: 'Times New Roman', serif ">58.8%) and 40 (41.2%)
cases were male and female, respectively. 7 (7.2%) of these children, 67
(69.1%) children's fathers and 16 (16.5%) of the children's mothers were opiate-dependent.
Seventy-one (73%) cases had been poisoned accidentally. Average time interval
to referring to hospital was 3.14</span><span style="font-family: 'Times New Roman', serif ">±</span><span style="font-family: 'Times New Roman', serif ">2.24 hours and average
used naloxone was 16.3</span><span style="font-family: 'Times New Roman', serif ">±12.7 </span><span style="font-family: 'Times New Roman', serif ">ampoules. The maximum
amount of referring was observed in autumn season and afternoon shifts. Twenty
(20.6%) and 53 (54.6%) poisoned children had severe and moderate risk signs,
respectively, and 24 (24.7%) cases were asymptomatic. </span><span style="font-family: 'Times New Roman', serif ">The
frequency and severity of methadone poisoning had a <a name="OLE_LINK7"></a><a name="OLE_LINK4"><span>statistically significant
association</span></a> (p<0.05) with variables including child addiction,
child's birth rank, mother addiction, mother age, mother educational level, and
family economic status.</span><span style="font-family: 'Times New Roman', serif "><o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Conclusion:</span></b><span style="font-family: 'Times New Roman', serif "> Season, mother
conditions, children addiction and birth rank, family economic status and
habitat are the most important factors in the incidence of methadone poisoning.<o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Key words:</span></b><span style="font-family: 'Times New Roman', serif "> Poisoning, Methadone,
Children</span><span style="font-family: 'Times New Roman', serif ">, frequency<o:p /></span></p>
<p class="MsoNormal" style="text-align: left line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-size: 3pt line-height: 150% font-family: 'Times New Roman', serif "><!--stripped--> <!--stripped--></span></b></p>
<p class="MsoNormal" style="text-align: left line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Funding</span></b><span style="font-family: 'Times New Roman', serif ">:</span><span style="font-family: 'Times New Roman', serif color: rgb(19, 20, 19) "> This
project was financially supported by Rafsanjan University of Medical Sciences </span></p>
<p class="MsoNormal" style="text-align: left line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Conflict
of interest</span></b><span style="font-family: 'Times New Roman', serif ">:</span><span style="font-family: 'Times New Roman', serif "> Authors</span><span style="font-family: 'Times New Roman', serif "> </span><span style="font-family: 'Times New Roman', serif ">have no conflict of
interest</span><span style="font-family: 'Times New Roman', serif "> to </span><span style="font-family: 'Times New Roman', serif ">declare</span><span lang="AR-SA" dir="RTL" style="font-family: 'Times New Roman', serif "><o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-family: 'Times New Roman', serif ">Ethical
approval: </span></b><span style="font-family: 'Times New Roman', serif ">the<b> </b></span><span style="font-family: 'Times New Roman', serif color: rgb(19, 20, 19) ">research</span><span style="font-size: 1pt line-height: 150% font-family: 'Times New Roman', serif color: rgb(19, 20, 19) "><span> </span></span><span style="font-family: 'Times New Roman', serif color: rgb(19, 20, 19) ">proposal was reviewed and approved in institutional ethics
committee and research council of Rafsanjan University of Medical Sciences<o:p /></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><span style="font-size: 3pt line-height: 150% font-family: 'Times New Roman', serif color: black "><!--stripped--> <!--stripped--></span></p>
<p class="MsoNormal" style="text-align: justify line-height: 150% direction: ltr unicode-bidi: embed "><b><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif color: black ">How to cite this article</span></b><b><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif ">:</span></b><b><span style="font-family: 'Times New Roman', serif "> </span></b><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif ">Masoudpour N, Zare</span><span dir="RTL"></span><span lang="FA" dir="RTL" style="font-size: 9pt line-height: 150% font-family: 'B Nazanin' "><span dir="RTL"></span>-</span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif ">Bidaki M, Sedighi E,
Bakhtar M</span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif ">. Frequency and Related Factors of Methadone
Poisoning in Children Aged under 15 Years Attending Children Emergency Center
of Rafsanjan Ali-Ebne-Abitaleb Hospital In 2013</span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif ">. <i><span style="color: black ">J RafsanjanUniv
Med Sci</span></i><span style="color: black "> </span></span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif color: black ">2015 14(7):</span><span style="font-size: 9pt line-height: 150% font-family: 'Times New Roman', serif color: black "> 561-74.
[Farsi]<o:p /></span></p>
مسمومیّت, متادون, کودکان, فراوانی
Poisoning, Methadone, Children, frequency
561
574
http://journal.rums.ac.ir/browse.php?a_code=A-10-698-3&slc_lang=fa&sid=1
N.
Masoudpour
ناهید
مسعودپور
dr_masoodpoor@yahoo.com
6900319475328460017789
6900319475328460017789
No
Rafsanjan University of Medical Sciences
دانشگاه علوم پزشکی رفسنجان
M.
Zare-Bidaki
محمد
زارع بیدکی
mzarebidaki@gmail.com
6900319475328460017790
6900319475328460017790
Yes
Rafsanjan University of Medical Sciences
دانشگاه علوم پزشکی رفسنجان
E.
Sedighi
عماد
صدیقی
emad6886@gmail.com
6900319475328460017791
6900319475328460017791
No
Rafsanjan University of Medical Sciences
دانشگاه علوم پزشکی رفسنجان
M.
Bakhtar
مرضیه
باختر
m.bakhtar2@gmail.com
6900319475328460017792
6900319475328460017792
No