fa اثر کافئین بر روی یادگیری و حافظه در موش صحرایی فارماكولوژي Pharmacology پژوهشي Research <p> <strong> The Effects of Caffeine on the Learning and Memory in Rats </strong></p><p>  </p><p> <strong> AR. Vahidi </strong><strong><sup /></strong>PharmD<strong>^1*</strong> <strong>, MH. Dasht </strong><strong>i </strong>PhD<strong>²</strong> </p><p>  </p><p> <strong> 1 </strong><strong>- Academic Member, Dept. </strong><strong>of Pharmacology, Shahid Sadoughi University of Medical sciences, Yazd, IRAN </strong></p><p> <strong> 2. Assistant Professor, Dept. of Physiology, Shahid Sadoughi </strong><strong>University of Medical sciences </strong><strong>, Yazd, IRAN </strong></p><p>  </p><p> <strong> Background: </strong>Caffeine as a methyl xanthine compound inhibits the breakdown of cyclic AMP, and causes an increase of the intracellular Ca⁺² of different cells. It also may be involved in enhancement of learning and memory via this rout. In this study the effect of caffeine on learning and memory has been evaluated. </p><p> <strong> Materials and Methods: </strong>In this study the effects of different concentrations of caffeine (10, 20, 40, 80 mg/kg), on the learning and memory in male rats weighting 250-300 gr, were evaluated. The rats (30) were divided into 5 groups (4 test groups and 1 control group). The effects were assessed by using the one way active avoidance method. The test groups recieved different doses of caffeine in 3ml/kg normal saline (N.S), and the animals in the control group recived only N.S (3ml/kg) intraperitoneally, 30 minutes before each test. </p><p> <strong> Results: </strong>The data obtained from the test group was compared with the control group statistically. Our results indicated that caffeine affect on learning and memory dose depently. Using 10 mg/kg caffeine significantly increased the mean percentage of learning (p<0.05), and the doses of (10, 20, 40 mg/kg) significantly elevated the level of short term memory. Although in the case of the long term memory all doses of caffeine (10, 20, 40 and 80 mg/kg) showed a significant difference between the test and the control groups, the result for 80 mg/kg dose was reversed. </p><p> <strong> Conclusion: </strong>Our results indicated that caffeine in low doses enhances the prosess of learning and memory but in higher doses it may suppress them. </p><p>  </p><p> <strong> Key words: </strong>Caffeine, Learning, Memory, Rat </p><p>  </p><p> <strong> *<i>Corresponding author Tel: (0351)6224824, Fax: (0351)7249331,</i> </strong><strong><i>E-mail:arvahidi@yahoo.com </i></strong></p><p> <strong><i> Journal of Rafsanjan University of Medical Sciences and Health Services, 2004, 3(3): </i></strong><strong><i /></strong><strong><i>180-187 </i></strong><strong></strong></p> ،کافئین،یادگیری،حافظه،موش صحرایی Caffeine, Learning, Memory, Rat 180 187 http://journal.rums.ac.ir/browse.php?a_code=A-10-133-1&slc_lang=fa&sid=1 AR. Vahidi علیرضا وحیدی arvahidi@yahoo.com 690031947532846002933 690031947532846002933 Yes MH. Dashti محمدحسین دشتی 690031947532846002934 690031947532846002934 No