Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.66224/jrums
fa
jalali
1397
12
1
gregorian
2019
3
1
17
12
online
1
fulltext
fa
اثر تمرین استقامتی و مقاومتی بر سطح سرمی اورکسین A، پروفایل لیپیدی و مقدار غذای مصرفی موشهای صحرایی نر سالم: یک مطالعه تجربی
The Effect of Endurance and Resistance Training on Serum Level of Orexin A, Lipid Profiles and Food Intake in Male Rats: An Experimental Study
تربيت بدني
تربيت بدني
پژوهشي
Research
<strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">چکیده</span></span></strong><strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"></span></span></strong><br>
<strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">زمینه و هدف:</span></span></strong> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">از آنجایی که </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">اورکسین دریافت غذا و مصرف انرژی را تنظیم می‏کند، لذا هدف مطالعه حاضر </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">تعیین</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> اثر تمرین استقامتی و مقاومتی بر سطح سرمی اورکسین </span></span><span dir="LTR"><span style="font-family:times new roman,serif;">A</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">، پروفایل لیپیدی و مقدار غذای مصرفی موش‏‏ صحرایی سالم بود.</span></span><br>
<a name="OLE_LINK26"></a><a name="OLE_LINK27"><strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">مواد و روش<em>‏</em>ها:</span></span></strong></a> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">در این مطالعه تجربی 36 سر موش صحرایی نر سالم </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">با سن 8 هفته</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> در محدوده وزنی 22±265 بهطور تصادفی به سه گروه (کنترل، تمرین استقامتی و تمرین مقاومتی) تقسیم شدند. گروه‏های تمرینی به مدت 8 هفته تمرینات </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">استقامتی و مقاومتی </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">منظم را انجام دادند. <a name="OLE_LINK148"></a><a name="OLE_LINK149">24 ساعت بعد از آخرین جلسه تمرین، سرم خون موش</a></span></span><span dir="LTR"><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">‎</span></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">ها جهت بررسی سطح سرمی اورکسین </span></span><span dir="LTR"><span style="font-family:times new roman,serif;">A</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> و پروفایل لیپیدی جمعآوری شد. داده</span></span><span dir="LTR"><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">‎</span></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">ﻫﺎ ﺑﺎ اﺳﺘﻔﺎده از آزﻣﻮن ﺗﺤﻠﯿﻞ واریﺎﻧﺲ یﮏﻃﺮﻓﻪ </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">و آزمون تعقیبی </span></span><span dir="LTR"><span style="font-family:times new roman,serif;">Tukey</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> تجزیه و تحلیل شدند</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">.</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;"></span></span><br>
<strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">یافته‏ها:</span></span></strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> تمرین استقامتی (04/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) و مقاومتی (011/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) موجب کاهش معنی</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">دار</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">سطوح سرمی اورکسین </span></span><span dir="LTR"><span style="font-family:times new roman,serif;">A</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> نسبت به گروه کنترل شد.</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">تمرین استقامتی (012/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) و مقاومتی (023/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) باعث کاهش معنی</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">دار</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">شاخص مقاومت به انسولین نسبت به گروه کنترل شد.</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> هم‏چنین کاهش معنی</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">داری در سطح سرمی تری‏گلیسرید </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">(001/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">و </span></span><span dir="LTR"><span style="font-family:times new roman,serif;">LDL</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">(002/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">)</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> در گروه تمرین استقامتی و کاهش معنی</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">داری در سطح سرمی تری‏گلیسرید </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">(017/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">)</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> و افزایش معنی</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"></span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">داری در </span></span><span dir="LTR"><span style="font-family:times new roman,serif;">HDL</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">(011/0</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P=</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">در گروه تمرین مقاومتی نسبت به گروه کنترل مشاهده شد. میانگین سطح غذای مصرفی در گروه تمرین استقامتی (03/0=</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) و گروه تمرین مقاومتی (18/0=</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">P</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">) نسبت به کنترل بی‏تمرین نیز کاهش معنیداری یافت.</span></span><br>
<strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">نتیجهگیری</span></span></strong><strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">:</span></span></strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> به نظر می</span></span><strong><span dir="LTR"><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">‎</span></span></span></strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">رسد تمرین </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">استقامتی و مقاومتی</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> از طریق کاهش سطوح سرمی </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">اورکسین ‏</span></span><span dir="LTR"><span style="font-family:times new roman,serif;">A</span></span> <span style="font-family:b nazanin;"><span style="font-size:12.0pt;">موجب کاهش غذای مصرفی و پروفایل لیپدی و شاخص مقاومت به انسولین می</span></span><strong><span dir="LTR"><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">‎</span></span></span></strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">شود.</span></span><br>
<strong><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">واژه‏های کلیدی:</span></span></strong> <a name="OLE_LINK85"></a><a name="OLE_LINK84"><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">اورکسین </span></span></a><span dir="LTR"><span style="font-family:times new roman,serif;">A</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">، شاخص مقاومت به انسولین، </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">پروفایل لیپیدی، </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">تمرین</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"> استقامتی، تمرین مقاومتی، </span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;">موش صحرایی</span></span><span style="font-family:b nazanin;"><span style="font-size:12.0pt;"></span></span><br>
<strong>Background and Objectives:</strong> Since orexin regulates food intake and energy expenditure, the<a name="OLE_LINK123"></a><a name="OLE_LINK122"> purpose of this study was to investigate the effect of endurance and resistance training on serum levels of orexin A, lipid profiles and dietary intake of healthy rats. </a><br>
<strong>Materials and Methods:</strong> In this experimental study, 32 healthy Wistar rats (8 weeks old) with a weight range of 265±22 were randomly divided into three groups (control, endurance training and resistance training). The exercise groups performed regular endurance and resistance training for 8 weeks. 24 hours after the last session of blood serum test, rats were collected to study serum levels of orexin A and lipid profiles. Data were analyzed using ANOVA and Tukey's post hoc test.<br>
<strong>Results: </strong>The endurance training (p=0.04) and resistance training (p=0.011) significantly decreased serum levels of orexin A compared to the control group. Endurance training (p=‏0.012) and resistance training (p=0.023) significantly decreased insulin resistance index compared to control group. Also, a significant decrease in serum triglyceride (p=0.001) and LDL (p=0.002) in the endurance training group and a significant decrease in serum triglyceride levels (p=0.017) and a significant increase in HDL (p=0.011) in the resistance training group compared to the control group. The mean of consumed food in the endurance training group (p=0.03) and resistance training group (p‏=‏0.18) decreased significantly compared to the control group.<br>
<strong>Conclusion</strong>: It seems that endurance and resistance training reduces serum levels of orexin A, which results in a decrease in food intake, lipid profiles and insulin resistance index.<br>
<strong>Key words</strong>: <a name="OLE_LINK97"></a><a name="OLE_LINK91">Orexin A, Insulin resistance index,</a> Lipid profiles, Endurance training, Resistance training, Rat<br>
<br>
<strong>Funding:</strong> The present research was based on a research project approved by the Deputy Director of Research and Technology at Arak University, which has been funded by this deputy.<br>
<strong>Conflict of interest</strong>: None declared.<br>
<strong>Ethical approval:</strong> The Ethics Committee of Arak University of Medical Sciences approved the study (‎IR.Arakmu.rec.1394.329).<br>
<br>
<strong>How to cite this article: </strong>Parastesh M, Saremi A. The Effect of Endurance and Resistance Training on Serum Level of Orexin A, Lipid Profiles and Food Intake in Male Rats: An Experimental Study . <em>J Rafsanjan</em> <em>Univ Med Sci</em> 2019; 17 (12): 1143-54. [Farsi]<br>
اورکسین A, شاخص مقاومت به انسولین, پروفایل لیپیدی, تمرین استقامتی, تمرین مقاومتی, موش صحرایی
Orexin A, Insulin resistance index, Lipid profiles, Endurance training, Resistance training, Rat
1143
1154
http://journal.rums.ac.ir/browse.php?a_code=A-10-1528-2&slc_lang=fa&sid=1
M.
Parastesh
محمد
پرستش
mohamad.parasteah@gmail.com
6900319475328460032516
6900319475328460032516
Yes
Department of Sport Physiology and Injury group, Faculty of Sport Sciences, Arak University, Arak, Iran
گروه فیزیولوژی و آسیب شناسی ورزشی، دانشکده علوم ورزشی، دانشگاه اراک، اراک، ایران
A.
Saremi
عباس
صارمی
a-saremi@araku.ac.ir
6900319475328460032517
6900319475328460032517
No
Department of Sport Physiology and Injury group, Faculty of Sport Sciences, Arak University, Arak, Iran
گروه فیزیولوژی و آسیب شناسی ورزشی، دانشکده علوم ورزشی، دانشگاه اراک، اراک، ایران