Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.66224/jrums
fa
jalali
1400
12
1
gregorian
2022
3
1
20
12
online
1
fulltext
fa
افزایش ریسک اختلالات کلیوی در بیماران مبتلا به کروناویروس 2019:
نامه به سردبیر
Increased Risk of Kidney Disorders in Patients with Coronavirus 2019:
A Letter to the Editor
فيزيولوژي
Physiology
گزارش كوتاه
Short Report
<span style="font-size:10pt"><span style="line-height:125%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="FA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">زمینه و هدف:</span></span></span></b> <span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">بیماری کرونا ویروس 2019 (کووید-19) به یک بیماری عالمگیر تبدیل شده است که میتواند اندامهای مختلف بدن انسان را درگیر نماید. اختلالات کلیوی در بیماران مبتلا به کووید-19 اغلب شایع است. درگیری در کلیهها به صورت پروتئینوری و آسیب حاد کلیه (</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:125%">Acute kidney injury; AKI</span></span><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">)</span></span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin""> ظاهر میشود</span></span></span><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">. این ویروس میتواند از طریق آنزیم مبدل آنژیوتانسین 2 (</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:125%">Angiotensin converting enzyme 2; ACE2</span></span><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">) منجر به نکروز حاد توبولی، نشت پروتئین در کپسول بومن، گلومرولوپاتی و اختلال میتوکندری شود. این ویروس همچنین میتواند باعث اختلال در تنظیم پاسخ</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:125%"></span></span><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">های ایمنی </span></span></span><span lang="FA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">(</span></span></span><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">از جمله طوفان سایتوکین)، فعال شدن نامتعادل سیستم رنین-آنژیوتانسین، فعال شدن نامتعادل ماکروفاژها در کلیهها شود.</span></span></span> <span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">از آنجایی که تا به امروز استراتژی درمانی اختصاصی برای محافظت از کلیه</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:125%"></span></span><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">ها در برابر کووید-19 وجود ندارد. لذا با توجه به نقش حیاتی کلیهها در حفظ هموستاز بدن، پیشنهاد میگردد در طول درمان بیماران مبتلا به کووید-19 توجه ویژهای به این اندام گردد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:125%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin"">واژههای کلیدی:</span></span></span></b><span lang="AR-SA" style="font-size:13.0pt"><span style="line-height:125%"><span style="font-family:"B Nazanin""> بیماری کووید-19، آسیب حاد کلیه، التهاب، پاسخ ایمنی، سیستم رنین-آنژیوتاسین</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:125%"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span dir="LTR" style="font-size:23.0pt"><span style="line-height:115%"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="line-height:160%">Background and Objectives: </span></b><span style="line-height:160%">Coronavirus 2019 (Covid-</span><span style="line-height:160%"><span style="font-family:"Calibri Light","sans-serif"">19</span></span><span style="line-height:160%">) has become a global disease that can affect various organs of the human body. Kidney disorders are the most common disorders in patients with Covid-</span><span style="line-height:160%"><span style="font-family:"Calibri Light","sans-serif"">19</span></span><span style="line-height:160%">. Kidney involvement manifests as proteinuria and acute kidney injury (AKI). This virus can cause acute tubular necrosis, protein leakage in the Bowman's capsule, glomerulopathy, and mitochondrial dysfunction via angiotensin-converting enzyme 2 (ACE2). It can also interfere with the regulation of immune responses (including cytokine storm), unbalanced activation of the renin-angiotensin system, and unbalanced activation of macrophages in the kidneys. To date, there is no specific treatment strategy to protect the kidneys against Covid-</span><span style="line-height:160%"><span style="font-family:"Calibri Light","sans-serif"">19</span></span><span style="line-height:160%">. Therefore, considering the vital role of the kidneys in maintaining body homeostasis, it is suggested that special attention be paid to this organ during the treatment of patients with Covid-</span><span style="line-height:160%"><span style="font-family:"Calibri Light","sans-serif"">19</span></span><span style="line-height:160%">.</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="line-height:160%">Key words: </span></b><span style="line-height:160%">Covid-</span><span style="line-height:160%"><span style="font-family:"Calibri Light","sans-serif"">19</span></span><span style="line-height:160%"> disease, Acute kidney injury, Inflammation, Immune response, Renin-angiotensin system</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" dir="RTL" style="line-height:160%"></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="line-height:160%">Funding: </span></b><span style="line-height:160%">None.</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="line-height:160%">Conflict of interest:</span></b><span style="line-height:160%"> None declared.</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="line-height:160%">Ethical approval:</span></b><span style="line-height:160%"> None declared.</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:160%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:160%"></span></span></b></span></span></span></span></span><br>
<b><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman","serif"">How to cite this article: </span></span></span></b><span style="font-size:10.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman","serif"">Kaeidi A, Hassanshahi<b> </b>J<b>. </b>Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor</span></span></span><span style="font-size:9.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman","serif"">. <i>J Rafsanjan</i></span></span></span><span style="font-size:9.0pt"><span style="line-height:107%"><span style="font-family:"Times New Roman","serif""> <i>Univ Med Sci</i> 2022; 20 (12): 1385-90 [Fars</span></span></span>
بیماری کووید-19, آسیب حاد کلیه, التهاب, پاسخ ایمنی, سیستم رنین-آنژیوتاسین
Covid-19 disease, Acute kidney injury, Inflammation, Immune response, Renin-angiotensin system
1385
1390
http://journal.rums.ac.ir/browse.php?a_code=A-10-1742-3&slc_lang=fa&sid=1
A.
Kaeidi
آیت
کائیدی
a.kayedi@gmail.com
6900319475328460048840
6900319475328460048840
No
Rafsanjan University of Medical Sciences
دانشگاه علوم پزشکی رفسنجان، رفسنجان
J.
Hassanshahi
جلال
حسن شاهی
hasanshahij@gmail.com
6900319475328460048841
6900319475328460048841
Yes
Rafsanjan University of Medical Sciences
دانشگاه علوم پزشکی رفسنجان، رفسنجان