Journal of Rafsanjan University of Medical Sciences
مجله دانشگاه علوم پزشکی رفسنجان
JRUMS
Medical Sciences
http://journal.rums.ac.ir
69
journal69
1735-3165
2008-7268
10.66224/jrums
fa
jalali
1401
4
1
gregorian
2022
7
1
21
4
online
1
fulltext
fa
تأثیر تمرین هوازی به همراه مصرف کورکومین بر بیان ژن شاخصهای آپوپتوزی بافت کبد موشهای سرطانی القایی پستان در فاز درمان با دوکسوروبیسین: یک مطالعه تجربی
The Effect of Aerobic Exercise with Curcumin Consumption on Tissue Apoptosis Indices in the Liver Tissue of Rats Induced by Breast Cancer in the Doxorubicin Treatment Phase:
An Experimental Study
تربيت بدني
تربيت بدني
پژوهشي
Research
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><v:roundrect arcsize="1475f" id="Rounded_x0020_Rectangle_x0020_25" o:gfxdata="UEsDBBQABgAIAAAAIQC75UiUBQEAAB4CAAATAAAAW0NvbnRlbnRfVHlwZXNdLnhtbKSRvU7DMBSF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=
" style="position:absolute; left:0; text-align:left; margin-left:20px; margin-top:1px; width:459pt; height:331.2pt; z-index:-251661824; v-text-anchor:top"> <w:wrap anchorx="margin"> </w:wrap></v:roundrect><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">چکیده</span></span></span></b></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">زمینه و هدف: </span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">شیمیدرمانی</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">عوارض زیادی بر بافت</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">ها</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">ی</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">ی مثل کبد دارد. هدف تحقیق حاضر تعیین تأثیر تمرین هوازی و­ کورکومین بر بیان­ژن شاخص­های­ آپوپتوزی بافت کبد موش­های سرطانی در فاز درمان با دوکسوروبیسین بود.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">مواد و روش­ها</span></span></span></b><b>:</b><b> </b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">تحقیق حاضر از نوع تجربی می­باشد. 36 سر موش ماده </span></span></span>Balb/c<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> با وزن </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۲</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%">±</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۲۰</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">گرم به صورت تصادفی به شش گروه تقسیم شد</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">ند</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">. کنترل سالم </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۱</span></span></span>G<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">، گروه کنترل سرطانی </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۲</span></span></span>G<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">، گروه بیمار+تیمار (مصرف داروی دکسوروبیسین) </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۳</span></span></span>G<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">، بیمار+تیمار+تمرین هوازی </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۴</span></span></span>G<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%">٬</span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">گروه بیمار+تیمار+مکمل </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۵</span></span></span>G<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> و گروه بیمار+تیمار+مکمل+تمرین هوازی </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۶</span></span></span>G<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">. جهت القاء سرطان پستان، رده سلولی </span></span></span>4T1<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> استفاده شد. دوکسوروبیسین به صورت </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">داخل </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">صفاقی در روزهای 21،14،7،1 و 28 تزریق شد و کورکومین، به حیوانات خورانده شد. تمرین هوازی شامل30 دقیقه دویدن با شدت60-40 درصد بیشینه سرعت، پنج روز در هفته به مدت 6 هفته بود. تمرینات در هفته اول با سرعت </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۱۴</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> متر در دقیقه و در هفته دوم به16 متر و در نهایت به </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۱۸</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">متر در دقیقه رسید. برای آنالیز دادهها از آنالیز واریانس یک­طرفه استفاده شد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">یافته­ها</span></span></span></b><b>:</b><b> </b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">اثر کورکومین و تمرین هوازی بر بیان­ ژن کاسپاز-3 (00</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۰۱/</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">0=</span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">)، (00</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">۰۱</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">/0=</span></span></span>P<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">) </span></span></span>Bcl2<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> از نظر آماری معنی</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">دار بود. در گروه 6 میزان بیان ­ژن </span></span></span> Bcl2<span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">نسبت به گروه­های دیگر افزایش داشت و کاسپاز-3 در گروه 5 و 6 نسبت به گروه 2 کاهش پیدا کرده بود</span></span></span>. <span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">نتیجه­گیری</span></span></span></b><b>:</b><span style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> احتمالاً تمرین هوازی به همراه مصرف نانوکورکومین در فاز درمانی با دوکسوروبیسین سازگاریهای لازم برای مهار یا توقف آپوپتوز را </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">در بافت کبد موش های مبتلا به سرطان پستان </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">فراهم میکند.</span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:110%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin"">واژه­های کلیدی:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:110%"><span style="font-family:"B Nazanin""> تمرین هوازی، کورکومین، آپوپتوز، سرطان پستان، کبد، دوکسوروبیسین</span></span></span><span dir="LTR" style="line-height:110%"></span></span></span></span></span></span><br>
<pre style="text-align:justify">
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Background and Objectives:</span></span></b> <span style="font-size:9.5pt"><span style="line-height:150%">Chemotherapy has many side effects on tissues such as the liver.The aim of this study was to evaluate the effect of aerobic exercise and curcumin on gene expression of apoptotic markers of liver tissue of cancer mice in doxorubicin treatment phase.</span></span><span lang="EN" style="font-size:9.5pt"><span style="line-height:150%"></span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">Materials and Methods:</span></span></b> <span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">The current research is of experimental type. 36 female Balb/c mice weighing 20±2 grams were randomly divided into six groups</span></span><span style="font-size:9.5pt"><span style="line-height:150%">: </span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">G</span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">1</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"> healthy control, G</span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">2</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"> patient control group, G</span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">3</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"> patient+treatment (doxorubicin drug use), G</span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">4</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"> patient+treatment+aerobic exercise, G</span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">5</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"> patient+treatment+supplement group, and G</span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">6</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"> patient+treatment+supplement+aerobic exercise group. 4T1 cell line was used to induce breast cancer. Doxorubicin was injected intraperitoneally on days </span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">1</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">, </span></span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">7</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">, </span></span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">14</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">, </span></span></span><span style="font-size:9.5pt"><span style="line-height:150%"><span style="font-family:"Calibri","sans-serif"">21</span></span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">, and 28, and curcumin was fed to the animals. Aerobic training consisted of 30 minutes of running with an intensity of 40-60% of maximum speed, five days a week for 6 weeks. In the first week, the exercises reached a speed of 14 meters per minute, and in the second week it reached 16 meters and finally 18 meters per minute. </span></span><span style="font-size:9.5pt"><span style="line-height:150%">O</span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">ne-way analysis of variance was used</span></span><span style="font-size:9.5pt"><span style="line-height:150%"> for data analysis.</span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Results:</span></span></b><span lang="EN" style="font-size:9.5pt"><span style="line-height:150%"> The effect of curcumin and aerobic exercise on the expression of Cas3 (p=0.0001) and Bcl2 (p=0.0001) genes was statistically significant. In group 6, Bcl2 gene expression increased compared to other groups, and Cas3 decreased in groups 5 and 6 compared to group 2.</span></span><span style="font-size:9.5pt"><span style="line-height:150%"></span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Conclusion</span></span></b><span style="font-size:9.5pt"><span style="line-height:150%">:</span></span> <span style="font-size:9.5pt"><span style="line-height:150%">Probably aerobic exercise combined with the use of nanocurcumin in the treatment phase with doxorubicin provides the necessary adaptations to inhibit or stop apoptosis in the liver tissue of mice with breast cancer.</span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">Key</span></span></b><b> </b><b><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">words</span></span></b><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">: Aerobic exercise, Curcumin, Apoptosis index, Breast cancer,</span></span><span lang="EN" style="font-size:9.5pt"><span style="line-height:150%"> Liver</span></span><span lang="X-NONE" style="font-size:9.5pt"><span style="line-height:150%">,</span></span> <span style="font-size:9.5pt"><span style="line-height:150%">Doxorubicin</span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:1.5pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Funding: </span></span></b><span style="font-size:9.5pt"><span style="line-height:150%">This study did not have any funds.</span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Conflict of Interest: </span></span></b><span style="font-size:9.5pt"><span style="line-height:150%">None declared.</span></span></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:150%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:150%">Ethical approval: </span></span></b><span style="font-size:9.5pt"><span style="line-height:150%">The Ethics Committee of Islamic Azad University of Parand of approved the study (IR.IAU.PIAU.REC.1400.019) </span></span><b><span dir="RTL" lang="AR-SA" style="font-size:3.5pt"><span style="line-height:150%"></span></span></b></span></span></span></span></span>
<span style="font-size:10pt"><span style="line-height:120%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:9.5pt"><span style="line-height:120%">How to cite this article:</span></span></b> <span style="font-size:9.0pt"><span style="line-height:120%">Sadeghian Solmaz, Kazemzadeh Yaser, Yahya Mohammadnejadpanah Kandi Yahya, Mirzayan Shanjani Sanaz, Sedaghati Saeed.</span></span><b> </b><span style="font-size:9.0pt"><span style="line-height:120%">The Effect of Aerobic Exercise with Curcumin Consumption on Tissue Apoptosis Indices in the Liver Tissue of Rats Induced by Breast Cancer in the Doxorubicin Treatment Phase: An Experimental Study. </span></span><i><span style="font-size:9.0pt"><span style="line-height:120%">J Rafsanjan</span></span></i><span style="font-size:9.0pt"><span style="line-height:120%"> <i>Univ Med Sci</i> 2022; 21 (4): 433-48. [Farsi]</span></span></span></span></span></span></span>
</pre>
تمرین هوازی, کورکومین, آپوپتوز, سرطان پستان, کبد, دوکسوروبیسین
Aerobic exercise, Curcumin, Apoptosis index, Breast cancer, Liver, Doxorubicin
433
448
http://journal.rums.ac.ir/browse.php?a_code=A-10-5867-1&slc_lang=fa&sid=1
Solmaz
Sadeghian
سولماز
صادقیان
solmazsadeghian64@gmail.com
6900319475328460050239
6900319475328460050239
No
Department of Sports Physiology, Faculty of Physical Education, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran
گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران.
Yaser
Kazemzadeh
یاسر
کاظم زاده
yaser.kazemzadeh@yahoo.com
6900319475328460050240
6900319475328460050240
Yes
Department of Sports Physiology, Faculty of Physical Education, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran
گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران.
Yahya
Mohammadnejadpanah Kandi
یحیی
محمدنژادپناه کندی
yahya_mnp@yahoo.com
6900319475328460050241
6900319475328460050241
No
Department of Sports Physiology, Faculty of Physical Education, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran
گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران.
Sanaz
Mirzayan Shanjani
ساناز
میرزایان شانجانی
san_mir2000@yahoo.com
6900319475328460050242
6900319475328460050242
No
Department of Sports Physiology, Faculty of Physical Education, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran
گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران.
Saeed
Sedaghati
سعید
صداقتی
sa49sd@gmail.com
6900319475328460050243
6900319475328460050243
No
Department of Sports Physiology, Faculty of Physical Education, Islamic Azad University, Islamshahr Branch, Islamshahr, Iran
گروه مدیریت ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد اسلامشهر، اسلامشهر، ایران