fa بررسی سطح سرمی سایتوکاین‌های TGF-β و IL-6 مؤثر بر سیستم ایمنی بیماران دیابتی مبتلا به عفونت انگلی توکسوپلاسما: یک گزارش کوتاه ايمونولوژي ايمونولوژي پژوهشي Research <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">زمینه و هدف: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">سایتوکاین‌ها نقش اساسی در تنظیم تعامل سلول‌های ایمنی در دیابت و عفونت‌هایی مانند توکسوپلاسموز دارند. این مطالعه با هدف تعیین سطوح سرمی </span></span></span>Transforming growth factor beta;TGF-&beta;<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> و </span></span></span>Interlukin-6;IL-6<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> در بیماران دیابتی مبتلا به توکسوپلاسموز انجام شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">مواد و روش</span></span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span cambria="" style="font-family:">‌</span></span></span></b><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">ها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> این مطالعه در شهرستان زابل بر روی بیماران دیابتی نوع </span></span></span>I<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> و </span></span></span>II<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> با و یا بدون مبتلا به توکسوپلاسموز انجام شد. سطح سرمی سایتوکاین‌های هدف با روش الایزا بررسی شد. داده‌ها </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">با آزمون </span></span></span>ANOVA<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> یک‌طرفه </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">تجزیه</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">‌و</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">‌تحلیل </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">شدند. جهت بررسی شاخص‌های دموگرافیک از آزمون کای اسکوئر استفاده شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">یافته‌ها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> افزایش معنی‌دار </span></span></span>TGF-&beta;<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> درگروه دیابت نوع </span></span></span>II<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> مبتلا به توکسوپلاسموز مشاهده شد. افزایش بسیار جزئی در سطح سرمی&nbsp; </span></span></span>IL-6<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> در گروه دیابتی نوع </span></span></span>I<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> مبتلا به توکسوپلاسموز مشاهده شد، اما سطح </span></span></span>TGF-&beta;<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> کاهش داشت.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:120%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">نتیجه‌گیری</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:">: مطالعه حاضر نشان داد که &nbsp;افزایش </span></span></span>TGF-&beta;<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> و کاهش </span></span></span>IL-6<span lang="FA" style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> در افراد مبتلا به دیابت نوع </span></span></span>II<span style="font-size:12.0pt"><span style="line-height:120%"><span b="" nazanin="" style="font-family:"> با توکسوپلاسموز می‌تواند نشانه‌ای از کاهش التهاب در این گروه از بیماران باشد.</span></span></span></span></span></span></span></span><br> <b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:">واژه‌های کلیدی:</span></span></span></b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" nazanin="" style="font-family:"> سایتوکاین‌ها، دیابت، توکسوپلاسموز، التهاب، ایمنی</span></span></span> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.0pt"><span style="line-height:140%">Background and Objectives:</span></span></b> <span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Cytokines play an essential role in regulating the interaction of immune cells in diabetes and infections such as toxoplasmosis. This study was conducted to investigate the serum levels of Interleukin-6 (IL-6) and Transforming Growth Factor-Beta (TGF-&beta;) in diabetic patients with toxoplasmosis.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Materials and Methods:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> This study was conducted in Zabol City on patients with type </span></span>I<span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> and type II diabetes, both with and without toxoplasmosis. The serum levels of target cytokines were measured using the ELISA method. Data analysis was performed using one-way ANOVA, and chi-square test was utilized to examine demographic indices.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Results:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> A significant increase in TGF-&beta; levels was observed in the group with type II diabetes and toxoplasmosis. Additionally, a slight rise in serum IL-6 levels was noted in the group with type </span></span>I<span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> diabetes. However, the level of TGF-&beta; was decreased in this group.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Conclusions:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> The present study revealed that an increase in TGF-&beta; and a decrease in IL-6 in patients with type II diabetes and toxoplasmosis may indicate a reduction in inflammation within this specific group.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Keywords:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> Cytokines, Diabetes, Toxoplasmosis, Inflammation, Immune</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Funding:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> This study was funded by Zabol University of Medical Sciences.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Conflict of interest:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> None declared.</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%">Ethical considerations:</span></span></b><span lang="EN-IN" style="font-size:9.0pt"><span style="line-height:140%"> The Ethics Committee of Zabol University of Medical Sciences approved the study (IR.ZBMU.REC.1400.074).</span></span><span dir="RTL" lang="FA" style="font-size:9.0pt"><span style="line-height:140%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Authors&rsquo; contributions:</span></span></b></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Conceptualization: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Javad Poursamimi, Mansour Debirzadeh</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Methodology: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Javad Poursamimi, Mansour Debirzadeh</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Data collection: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Javad Poursamimi, Mansour Debirzadeh, Roghayeh Hossein Beigi</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Formal analysis: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Javad Poursamimi</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Supervision: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Javad Poursamimi</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Project administration:</span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%"> Javad Poursamimi</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Writing - original draft: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Javad Poursamimi, Mansour Debirzadeh</span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:140%"><span style="tab-stops:-45.0pt"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">- Writing - review & editing: </span></span></b><span lang="EN" style="font-size:9.0pt"><span style="line-height:140%">Ladan Arab Yaqoubi</span></span><b><span style="font-size:8.0pt"><span style="line-height:140%"></span></span></b></span></span></span></span></span><br> &nbsp; سایتوکاین‌ها, دیابت, توکسوپلاسموز, التهاب, ایمنی Cytokines, Diabetes, Toxoplasmosis, Inflammation, Immune 264 272 http://journal.rums.ac.ir/browse.php?a_code=A-10-6582-2&slc_lang=fa&sid=1 Mansour Dabirzadeh منصور دبیرزاده 6900319475328460058353 6900319475328460058353 No دانشگاه علوم پزشکی زابل Roghayeh Hossein Beigi رقیه حسین بیگی dr.rh.beighy@gmail.com 6900319475328460058354 0009-0002-1941-4150 No دانشجوی تخصصی داخلی، گروه داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران Javad Poursamimi جواد پورصمیمی Poursj1357@zbmu.ac.ir 6900319475328460058355 6900319475328460058355 Yes دانشگاه علوم پزشکی زابل Ladan Arab Yaghoobi لادن عرب یعقوبی Ladan.yaqoubi@gmailcom 6900319475328460058356 6900319475328460058356 No Zahedan University of Medical Sciences دانشگاه علوم پزشکی زاهدان