69 1735-3165 Journal of Rafsanjan University of Medical Sciences 37 Pediatrics Comparision of the Recall Rate Using Two Different Diagnostic Criteria at Isfahan Screening Program for Congenital Hypothyroidism Hashemipour M. Iranpour R. Amini M. Hovsepian S. Haghighi S. 1 6 2004 3 3 134 140 04 12 2005
38 Physiology The Effect of Oral Lecithin on Spatial Learning of Adult Male Rats Afarinesh M. Moazedi AA. Abbasnejad M. 1 6 2004 3 3 141 148 04 12 2005 39 cardiology The Effects of Oral Theophylline in Patients with Cardiac Syndrome X Mokhberi V. Mohseni Kyasari A. Bagheri B. 1 6 2004 3 3 149 155 04 12 2005 40 Physiology The Effects of Stabilizing Exercises in the Patients with Lumbar Disc Hernia Bakhtiari AH. Safavi Farrokhi Z. Ashtari Z. 1 6 2004 3 3 156 164 04 12 2005 41 طب کار Study of the Liver Function in a Plastic Processing Industry Workers Exposed to Styrene in 1382 (2003) Aminian O. Rafeemanesh E. Sharifian A. Abbasi M. 1 6 2004 3 3 165 171 05 12 2005 42 Anatomy The Relation of Maternal Hypothyroidism and Dendritic Spines Reduction in Brain Pyramidal Cells of Balb/C Mice Jalali M. Nikravesh MR. 1 6 2004 3 3 172 179 05 12 2005 43 Pharmacology The Effects of Caffeine on the Learning and Memory in Rats Vahidi AR. Dashti MH. 1 6 2004 3 3 180 187 05 12 2005   The Effects of Caffeine on the Learning and Memory in Rats     AR. Vahidi PharmD1* , MH. Dasht i PhD2     1 - Academic Member, Dept. of Pharmacology, Shahid Sadoughi University of Medical sciences, Yazd, IRAN   2. Assistant Professor, Dept. of Physiology, Shahid Sadoughi University of Medical sciences , Yazd, IRAN     Background: Caffeine as a methyl xanthine compound inhibits the breakdown of cyclic AMP, and causes an increase of the intracellular Ca+2 of different cells. It also may be involved in enhancement of learning and memory via this rout. In this study the effect of caffeine on learning and memory has been evaluated.   Materials and Methods: In this study the effects of different concentrations of caffeine (10, 20, 40, 80 mg/kg), on the learning and memory in male rats weighting 250-300 gr, were evaluated. The rats (30) were divided into 5 groups (4 test groups and 1 control group). The effects were assessed by using the one way active avoidance method. The test groups recieved different doses of caffeine in 3ml/kg normal saline (N.S), and the animals in the control group recived only N.S (3ml/kg) intraperitoneally, 30 minutes before each test.   Results: The data obtained from the test group was compared with the control group statistically. Our results indicated that caffeine affect on learning and memory dose depently. Using 10 mg/kg caffeine significantly increased the mean percentage of learning (p<0.05), and the doses of (10, 20, 40 mg/kg) significantly elevated the level of short term memory. Although in the case of the long term memory all doses of caffeine (10, 20, 40 and 80 mg/kg) showed a significant difference between the test and the control groups, the result for 80 mg/kg dose was reversed.   Conclusion: Our results indicated that caffeine in low doses enhances the prosess of learning and memory but in higher doses it may suppress them.     Key words: Caffeine, Learning, Memory, Rat     *Corresponding author Tel: (0351)6224824, Fax: (0351)7249331, E-mail:arvahidi@yahoo.com   Journal of Rafsanjan University of Medical Sciences and Health Services, 2004, 3(3): 180-187 90 غدد Changes of Body Mass Index in Turner Syndrome Before and after Growth Hormone Therapy Vakili R. Horry M. Motaghi Moghaddam H. 1 6 2004 3 3 188 192 11 12 2005 44 Gynecology Prevalence of Anemia in 15-45 Year old Women Referring to the Health Centers of Bam, 2002 Arab M. Abbasszadeh A. Abazary F. Nikian Y. 1 6 2004 3 3 193 198 05 12 2005 45 Rehabilitation The Effects of Strengthening Exercises on Exaggerated Muscle Tonicity on the Chronic Hemiparesis Patients After Stroke Akbari A. Karimi H. Kazemnegad A. Ghabaii M. 1 6 2004 3 3 199 206 05 12 2005