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URL: http://journal.rums.ac.ir/article-1-2191-en.html
Background
and Objective: Insulin
regulates many important processes in the central nervous system such as
synaptic plasticity, learning and memory.
Experimental evidence suggest a link between type 2 diabetes and Alzheimer’s
disease (AD). Insulin modulates the metabolism of beta-amyloid precursor
protein in neurons, decreasing the intracellular accumulation of beta-amyloid.
The aim of the present study was to investigate the effects of intraventricular
injection of Metformin on memory retention in streptozotocin (STZ) rat model of
Alzheimer's disease.
Materials
and Methods: A
total of 56 male wistar rats (200-250 gr) were divided into 7 groups (n=8): Control,
Sham, STZ, STZ +Salin, STZ +Metformin. For induction of AD, STZ (3 mg/kg,
i.c.v, 10 μl each) were
administered bilaterally into latral ventricles. Two weeks later all
rats were trained in one trial step-through passive avoidance learning. Saline (5 ul) or Metformin (50,100,200ug/kg,
5 ul, i.c.v) were injected
through the guide cannula immediately after training. Retention test was
done two days later.
Results: Our results showed that
post-training microinjection of Metformin into lateral ventricles improves
memory retention in STZ rat model of AD in a dose dependent manner, so that the time spent in the light chamber
before entering to the
dark area in the STZ + Metformin
(200ug/kg) group rats were
significantly more than STZ group.
Conclusion: The results indicated that Metformin is useful
for treatment of Alzheimer's disease.
Key
words: Alzheimer,
Metformin, Intraventricular, Passive avoidance learning, Memory retention,
Streptozotocin
Funding: This research was funded by
Qazvine University of Medical Sciences.
Conflict
of interest: None
declared.
Ethical
approval: The
Ethics Committee of Qazvine University of Medical Scinces approved the study.
How
to cite this article: Haghdost
H, Esmaeili MH, Sofiabadi M, Rastak S, Heydari B, Charmchi Z, Ghasemi L.
Effects of Metformin Microinjection into Lateral Ventricles on Memory Retention
of Streptozotocin Rat Model of Sporadic Alzheimer's Disease.. J RafsanjanUniv Med Sci 2014
14(3):
222-211. [Farsi]
Received: 2014/06/10 | Accepted: 2015/04/8 | Published: 2015/06/6
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