Volume 19, Issue 7 (10-2020)
JRUMS 2020, 19(7): 749-764 |
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Zeinoddini M. Reasons for the Creation of the New Coronavirus 2019 (SARS-CoV2): Natural Mutation or Genetically Laboratory Manipulation-Point of View. JRUMS 2020; 19 (7) :749-764
URL: http://journal.rums.ac.ir/article-1-5264-en.html
URL: http://journal.rums.ac.ir/article-1-5264-en.html
Malech Ashtar University of Technology
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Reasons for the Creation of the New Coronavirus 2019 (SARS-CoV2): Natural Mutation or Genetically Laboratory Manipulation-Point of View
M. Zeinoddini [1]
Received: 05/05/2020 Sent for Revision: 29/06/2020 Received Revised Manuscript: 09/08/2020 Accepted: 09/08/2020
Background and Objectives: Following the emergence of COVID-19 caused by the SARS-CoV2, the reasons for the emergence of the novel virus have been the subject of interest for molecular biology researchers and news agencies. This article attempted to emphasize all aspects of the emergence of this virus and discuss the latest information related to its development.
Materials and Methods: From the main site for articles published on COVID-19 (LitCovid), more than 34000 articles have been published, until July 22. But there have been been no scientific discussion about the reasons for the emergence of the virus due to its natural origin or genetic manipulation in research laboratories. In this review study, by collecting and reviewing 15 articles related to this topic, the scientific reasons for the emergence of this virus is analyzed.
Results: Reverse genetic technology is a powerful tool for genetic instructions and design of engineered viruses to produce effective drugs and vaccines against viral infections. But dangerous viruses may also be created in this way that exhibit unknown properties. Studies have shown that SARS-CoV2 has a unique sequence in the middle of the gene encoding glycoprotein Spike (S) that is not similar to other coronaviruses.
Conclusion: Due to the specific features of SARS-CoV 2 and its comparison with other coronaviruses, its emergence and novel agents has been determined in the scientific community. For this, laboratory production and genetic manipulation are possible, but whether its occurrence is accidental or intentional requires further investigation.
Key words: SARS-CoV2, Recombinant virus, COVID-19, Genetic manipulation, Mutation.
Ethical approval: None declared.
Funding: This study did not have any funds.
Conflict of interest: None declared.
How to cite this article: Zeinoddini M. Reasons for the Creation of the New Coronavirus 2019 (SARS-CoV2): Natural Mutation or Genetically Laboratory Manipulation-Point of View. J Rafsanjan Univ Med Sci 2020; 19 (7): 749-64. [Farsi]
[1]- Associate Prof. of Biochemistry, Faculty of Chemistry and Chemical Engineering, Malek Ashtar University of Technology, Iran
ORCID: 0000-0002-9500-1334
Tel: (021) 22974600, Fax: (021) 22974605, E-mail: zeinoddini52@mut.ac.ir
M. Zeinoddini [1]
Received: 05/05/2020 Sent for Revision: 29/06/2020 Received Revised Manuscript: 09/08/2020 Accepted: 09/08/2020
Background and Objectives: Following the emergence of COVID-19 caused by the SARS-CoV2, the reasons for the emergence of the novel virus have been the subject of interest for molecular biology researchers and news agencies. This article attempted to emphasize all aspects of the emergence of this virus and discuss the latest information related to its development.
Materials and Methods: From the main site for articles published on COVID-19 (LitCovid), more than 34000 articles have been published, until July 22. But there have been been no scientific discussion about the reasons for the emergence of the virus due to its natural origin or genetic manipulation in research laboratories. In this review study, by collecting and reviewing 15 articles related to this topic, the scientific reasons for the emergence of this virus is analyzed.
Results: Reverse genetic technology is a powerful tool for genetic instructions and design of engineered viruses to produce effective drugs and vaccines against viral infections. But dangerous viruses may also be created in this way that exhibit unknown properties. Studies have shown that SARS-CoV2 has a unique sequence in the middle of the gene encoding glycoprotein Spike (S) that is not similar to other coronaviruses.
Conclusion: Due to the specific features of SARS-CoV 2 and its comparison with other coronaviruses, its emergence and novel agents has been determined in the scientific community. For this, laboratory production and genetic manipulation are possible, but whether its occurrence is accidental or intentional requires further investigation.
Key words: SARS-CoV2, Recombinant virus, COVID-19, Genetic manipulation, Mutation.
Ethical approval: None declared.
Funding: This study did not have any funds.
Conflict of interest: None declared.
How to cite this article: Zeinoddini M. Reasons for the Creation of the New Coronavirus 2019 (SARS-CoV2): Natural Mutation or Genetically Laboratory Manipulation-Point of View. J Rafsanjan Univ Med Sci 2020; 19 (7): 749-64. [Farsi]
ORCID: 0000-0002-9500-1334
Tel: (021) 22974600, Fax: (021) 22974605, E-mail: zeinoddini52@mut.ac.ir
Type of Study: Review Article |
Subject:
مديريت و اطلاع رساني پزشكي
Received: 2020/04/25 | Accepted: 2020/09/9 | Published: 2020/10/19
Received: 2020/04/25 | Accepted: 2020/09/9 | Published: 2020/10/19
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