Volume 2, Number 1 (6-2003)                   JRUMS 2003, 2(1): 52-60 | Back to browse issues page


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Fathi Moghaddam H, Kesmati M, Mohammadpour kargar H. The Effect of Clonidine Administration into Lateral Paragigantocellularis on Morphine Withdrawal in Morphine Dependent Male Rats. JRUMS. 2003; 2 (1) :52-60
URL: http://journal.rums.ac.ir/article-1-59-en.html

استاديار گروه فيزيولوژي
Abstract:   (10107 Views)

  The Effect of Clonidine Administration into Lateral Paragigantocellularis on Morphine Withdrawal in Morphine Dependent Male Rats

 

  H. Fathi Moghaddam 1, M. Kesmati 2, H. Mohammadpour kargar 3

 

  1-Department of Physiology, School of Medicine, Ahwaz University of Medical Sciences, Ahwaz, Iran

  2-Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahwas, Iran

  3- Academic Member, Department of Biology, Islamic Azad Universuty, Damghan, Iran

 

 Background: Paragigantocellularis plays a role in different physiologic actions. In this study the effect of clonidine administration into lateral paragigantocellularis on morphine withdrawal syndrome in male rat was investigated.

 Materials and Methods: Rats were addicted to morphine by injecting 25, 30, 35, and 40 mg/kg ip twice a day for four days. In the fifth day rats received 40 mg/kg morphine and after half an hour naloxane hydrochloride (2mg/kg, ip) for morphine withdrawal. Clonidine which is an alpha-2 adrenoceptor agonist was administered in doses of 1 & 2 ug/0.5ul to lateral paragigantocellularis 5 minutes before naloxane injection. Number of chewing, jumping, standing on feet, ejaculation, Paw tremor, and defecating were evaluated half an hour after naloxane injection.

 Results: The results showed that clonidine decreased the number of chewing, paw tremor and ptosis time, but had no effect on teeth gnashing, grooming and wet dog shakes.

 Conclusion: It can be proposed that alpha-2 adrenocepors in LPGi could mediate clonidine effects on withdrawal syndrome.

 

 Keyword: Clonidine, Paragigantocellularis Nucleus, Wet Dog Shakes, Morphine,

 Withdrawal Syndrome.

 

 

  Corresponding author,tel:(0611) 3334694

Journal of Rafsanjan University of Medical Sciences and Health Services, 2002, 2(1): 52-60

 

Full-Text [PDF 277 kb]   (1707 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2005/12/8

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