Volume 20, Issue 12 (3-2022)
JRUMS 2022, 20(12): 1385-1390 |
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Kaeidi A, Hassanshahi J. Increased Risk of Kidney Disorders in Patients with Coronavirus 2019:
A Letter to the Editor. JRUMS 2022; 20 (12) :1385-1390
URL: http://journal.rums.ac.ir/article-1-6440-en.html
URL: http://journal.rums.ac.ir/article-1-6440-en.html
Rafsanjan University of Medical Sciences
Keywords: Covid-19 disease, Acute kidney injury, Inflammation, Immune response, Renin-angiotensin system
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Increased Risk of Kidney Disorders in Patients with Coronavirus 2019:
A Letter to the Editor
A. Kaeidi[1], J. Hassanshahi[2]
Received: 24/01/22 Sent for Revision: 29/01/22 Received Revised Manuscript: 09/02/22 Accepted: 09/02/22
Background and Objectives: Coronavirus 2019 (Covid-19) has become a global disease that can affect various organs of the human body. Kidney disorders are the most common disorders in patients with Covid-19. Kidney involvement manifests as proteinuria and acute kidney injury (AKI). This virus can cause acute tubular necrosis, protein leakage in the Bowman's capsule, glomerulopathy, and mitochondrial dysfunction via angiotensin-converting enzyme 2 (ACE2). It can also interfere with the regulation of immune responses (including cytokine storm), unbalanced activation of the renin-angiotensin system, and unbalanced activation of macrophages in the kidneys. To date, there is no specific treatment strategy to protect the kidneys against Covid-19. Therefore, considering the vital role of the kidneys in maintaining body homeostasis, it is suggested that special attention be paid to this organ during the treatment of patients with Covid-19.
Key words: Covid-19 disease, Acute kidney injury, Inflammation, Immune response, Renin-angiotensin system
Funding: None.
Conflict of interest: None declared.
Ethical approval: None declared.
How to cite this article: Kaeidi A, Hassanshahi J. Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor. J Rafsanjan Univ Med Sci 2022; 20 (12): 1385-90 [Farsi]
A Letter to the Editor
A. Kaeidi[1], J. Hassanshahi[2]
Received: 24/01/22 Sent for Revision: 29/01/22 Received Revised Manuscript: 09/02/22 Accepted: 09/02/22
Background and Objectives: Coronavirus 2019 (Covid-19) has become a global disease that can affect various organs of the human body. Kidney disorders are the most common disorders in patients with Covid-19. Kidney involvement manifests as proteinuria and acute kidney injury (AKI). This virus can cause acute tubular necrosis, protein leakage in the Bowman's capsule, glomerulopathy, and mitochondrial dysfunction via angiotensin-converting enzyme 2 (ACE2). It can also interfere with the regulation of immune responses (including cytokine storm), unbalanced activation of the renin-angiotensin system, and unbalanced activation of macrophages in the kidneys. To date, there is no specific treatment strategy to protect the kidneys against Covid-19. Therefore, considering the vital role of the kidneys in maintaining body homeostasis, it is suggested that special attention be paid to this organ during the treatment of patients with Covid-19.
Key words: Covid-19 disease, Acute kidney injury, Inflammation, Immune response, Renin-angiotensin system
Funding: None.
Conflict of interest: None declared.
Ethical approval: None declared.
How to cite this article: Kaeidi A, Hassanshahi J. Increased Risk of Kidney Disorders in Patients with Coronavirus 2019: A Letter to the Editor. J Rafsanjan Univ Med Sci 2022; 20 (12): 1385-90 [Farsi]
[1]- Associate Prof. of Physiology, Dept. of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, ORCID: 0000-0002-3292-2603
[2]- Assistant Prof. of Physiology, Dept. of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, ORCID: 0000-0003-3754-8152
(Corresponding Author) Tel: (034) 31315083, Fax: (034) 31315003, E-mail: hasanshahij@gmail.com
(Corresponding Author) Tel: (034) 31315083, Fax: (034) 31315003, E-mail: hasanshahij@gmail.com
Type of Study: Short Report |
Subject:
Physiology
Received: 2022/02/22 | Accepted: 2022/03/9 | Published: 2022/03/19
Received: 2022/02/22 | Accepted: 2022/03/9 | Published: 2022/03/19
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