Effects of Tamsolusin on Serum Testosterone and Gonadotropins Concentration in Adult Male Rats
M. Mokhtari PhD , M. Shariati PhD , J. Amiri MSc
Received: 06/06/06 Sent for Revision: 18/10/06 Received Revised Manuscript: 25/11/06 Accepted: 27/01/07
Background and Objective: Tamsulosin hydrochloride (HCl) is an alpha-1 adrenoceptor antagonist and its ability to inhibit alpha-1 adrenoceptor is more than alpha-2 adrenoceptor. Due to the important therapeutic role of Tamsulosin HCl in benign prostatic hyperplasia (BPH), its side effects on the endocrine axes are also very important. The aim of the present research was to determine the effect of Tamsulosin HCl on serum level of testosterone and gonadotropins , and also on the spermatogengsis in adult male rats .
Materials and Methods: In this experimental study, 40 adult male Wistar rats were randomly divided into 5 groups of 8. The experimental groups received 100, 300, and 600 mg/kg/day of Tamsulosin for 28 days. The sham group were treated with distilled water and the control group received nothing. The blood samples were taken on day 28 and the blood concentration of LH, FSH and testosterone were measured by RIA. Simulataneously, the testes of all rats were removed to assess the possible histological changes. The results were analysed using ANOVA and Duncan tests. The level of significance was considered at p≤0.05.
Results: The results indicated that at doses used in our study, Tamsulosin HCl had no significant effect on serum LH and FSH. However, this drug at high concentration was able to decrease the level of testostrone. Also, our histological studies showed a decrease in density of spermatoza in the seminiferous tubules in some sections only at high doses of the drug.
Conclusion: According to this research and the results from other similar studies, Tamsulosin at high dose is possibly able to decrease the serum oncentration of testostrone through either the effect on steroidogenesis enzymes in testes, or its inactivation properties on adrenergic and serotonergic systems involved in steroidogenesis. So, it seems that alpha adrenergic receptor blockers possibly have some deleterious effect on spermatogenesis causing infertility in male rats. However further studies need to confirm these results.
Key words: Tamsulosin, Testosterone, Gonadotropins, Rats
The Correlation of the Duration of Flaccidity Period and the Intensity and Location of the Disorder in Patients with Cerebro-Vascular Accident
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N. Tahan [1] , Kh. Khademi Kalantari [2] , Y. Kholghi [3] , Z. Amiri [4]
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Received: 03/11/08 Sent for Revision: 01/03/09 Received Revised Manuscript: 13/09/09 Accepted: 25/10/09
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Background and Objectives: Motor deficit in the shape of muscle flaccidity after Cerebro-vascular Accident (CVA) is a common disorder. As the duration of the flaccidity period extends, the motor recovery is delayed proportionally. In this study, the correlated factors to the length of flaccidity period and the final prognosis of the patients with CVA have been investigated.
Materials and Methods: In this descriptive study, in a 6 months time (Apr-Oct, 2007), all the patients (110) with cerebral vascular disease who were admitted to the neurological ward of Loghman hospital entered in the study. An information form regarding the standard motor evaluation charts of Adams and Oxfordish was completed for each patient. The patients with total flaccidity were reassessed for their motor recovery at 72 hours, 1, 2 and 4 weeks after their cerebro-vascular accident.
Results: Out of 110 investigated cases, 29 patients (26.4%) had total flaccidity at the onset of the study. Twelve patients out of this group (41.4%) had partial anterior infarction, however the majority of the patients with normal muscular tonus (34 cases) had lacuner lesion [23 patients (67.64%). The patients with total flaccidity had shorter flaccidity period compared to the patients with partial anterior infarction.
Conclusions: The results showed that the occlusive lesions of anterior circulation and lacuner are the most common lesions, and it seems that the patients with partial anterior infarction have poorer prognosis regarding their motor recovery than that of others.
Key words : Flaccidity, Cerebro-Vascular Accident, Motor Recovery, Intensity and Location of Disorder
Funding: This research was funded by Shahid Beheshti University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval : The Ethical Committee of Shahid Beheshti University of Medical Sciences approved the study.
[1] - Instructor and PhD Student, Dept. of Physiotherapy, Shahid Beheshti University of Medical Sciences, Tehran Iran
[2] - Associate Prof., Dept. of Physiotherapy, Shahid Beheshti University of Medical Sciences, Tehran Iran
(Corresponding Author) Tel: (021)77561411, Fax: (021) 77561406, E-mail: khosro_khademi@yahoo.com
[3] - Assistant Prof, Dept. of Neurology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran Iran
[4] - Assistant Prof, Dept. of Statistics, Faculty of Neutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background and Objectives: This study aimed to determine the prevalence of presbyopia in patients examined in Optometry clinic of Faculty of Rehabilitation of Shahid Beheshti Medical Univessity.
Meterials and Methods : In this crosse- sectional study, 600 files of the patients examined in the optometry clinic of Rehabilitation Faculty of Shahid Beheshti Medical university in year 2008/2009 were analyzed. Variables included age, sexe, amount and type of refractive errors, presbyopia and health of anterior and posterior eye segment. The patients were divided into two groups: groupe 1, included the pattients ages less than 40 and groupe 2, patients ages 40 years and older. Groupe 2, were divided. The deta were analyzed using X2 and descriptive test.
Results : The mean and standard deviation of ages of all the 600 patients' was 34.21±21 and for presbyopic patients was 55.53±10.9 years. Prevalence of presbyopia in total population was 41% and in population over 40 years, was 92.5%. From 246 presbyopic patients, 131 cases (53.3%) were females and 115 cases (46.7%) were males. There was a significant statistica l difference between the presbyopia patients compared to the other groups (p<0.0001) but this different between men and women was not significant (p= 0.23).
Conclusion: In this study, the prevalence of presbyopia increased with aging. The prevalence of presbyopia in hypermetropia patients was more than myopic patients.
Key word s: Presbyopia, Refractive error, Age and gender
Funding : This research was funded by Shahid Beheshti Medical University.
Conflict of intrest: None declared.
Ethicts committe aproval: The nummer of 87-01-93-5971- December 22, 2009 Shahid Beheshti Medical University.
How to cite this article : Akhgary M, Aghazadeh Amiri M , Ghassemi- Broumand M, Tabatabaee SM. Prevalence of Presbyopia in Patients Examined in Optometry Clinic Affiliated with Rehabilitation Faculty of Shahid Beheshti Medical University . J Rafsanjan Univ Med Scie 2013 11(6): 599-604. [Farsi]
Background
and Objective: Pregnancy is a major event in a woman's life that can bring a lot of
stress for her. Fear of childbirth is a common problem
for pregnant women. This fear can be a predictor
of caesarean section in them. This study aimed
to investigate the causes of fear of childbirth in pregnant
women in Shahrekord.
Materials
and Methods: This
descriptive-cross-sectional study was performed on 130 pregnant women referred
to health
centers in Shahrekord city. Fear of Childbirth Questionnaire was
used to collect the data. For data analysis, it was used descriptive and analytical
statistics (Pearson's correlation coefficient and t-test).
Results:
The results
showed that, the main cause of fear of childbirth in pregnant women was fear of
painful injections during labor. The mean score for fear of delivery in multiparous
women was significantly greater than the nulliparous women (p<0.001).
Conclusions:
Concerningthe
increase of caesarean rates, it is important that health care providers pay more
attention to the causes of this fear.
Key words: Fear, Childbirth, pregnant woman
Funding: This research was funded by Isfahan
University of Medical Sciences.
Conflict of interest: None declared.
Ethical
approval: The
Ethics Committee of Esfahan University of Medical Sciences approved the study.
How to cite this article: Taheri Z, Khorsandi M, Amiri M,
Hasanzade A. Investigating the Causes of Fear
of Childbirth in
Shahrekord Pregnant Women, in 2013: A Short
Report. J RafsanjanUniv Med Sci 2015
14(4):
345-50. [Farsi]
Background and Objectives: Diabetes is a chronic and progressive disease that due to its nature, it needs the cooperation of patient in the treatment process. This disease has been developed with industrialization and urbanization. Patient empowerment program is an effective program to improve the function of patients with diabetes. The purpose of this study, was the evaluation of empowerment-based interventions in patients with diabetes.
Materials and Methods: We conducted a comprehensive overview in internatioanl and Iranian databases including Science Direct, PubMed, Cochrane library, Scopus, Iranmedex,and Google Scholar with the keywords of “empowerment”, “empowerment approach”, “empowerment program”, “patient empowerment”, “empowerment and diabetes” and “diabetic patients” from 2000 to 2014. After considering inclusion and exclusion criteria, 16 articles were selected.
Results: The results indicated that there was a lack of existence of a theoretical framework of empowerment, lack of attention to all dimensions of empowerment and the impact of demographic variables on empowerment of patients, and lack of programme follow- up.
Conclusion: Due to the limitations specified in empowerment interventions, it is suggested that interventions in diabetic patients should pay attention to all dimensions of empowerment.
Key words: Empowerment, Diabetes, Review, Patient
Funding: This research was funded by Shahrekord University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Shahrekord University of Medical Sciences approved the study.
How to cite this article: Taheri Z, Khorsandi M, Taheri Z, Ghafari M, Amiri M. Empowerment-based interventions in patients with diabetes: A review study J Rafsanjan Univ Med Sci 2016; 15(5): 452-68. [Farsi]
Background and Objective: According to the importance of health systems, assessing the different aspects of health care service quality comes into necessity. This assessment has not been done in Rafsanjan School of Dentistry yet. The purpose of this study was assesing and analysing the existing gap within service performance quality in clinical departments of this school.
Materials and Methods: This descriptive study was carried out in 2016-2017 academic year. Participants were 180 patients of clinical departments of Rafsanjan Dental School. Data were collected by SERVQUAL standard questionnaire which assesses quality of services in six dimentions and 31 questions and then analysed. In data analysis, independent t- test, paired t -test and one-way ANOVA were used.
Results: A significant gap (p<0.001) was reported in all dimentions of the questionnaire and between expectations and perceptions. The largest gap pertained to the dimention of accessibility (-1.57±0.91) and the lowest was related to the dimention of assurance (-1.37±0.58). The total mean of gap of this questionnaire was calculated -1.24±0.34 for this faculty. "In time service providing” had the largest gap among all of the questions (-2.26±1.06). Largest gap between clinical departments was reported for oral medicine department (-2.40±0.63).
Conclusion: Regarding to lack of relative satisfaction which was seen in all dimentions, measures, and clinical departments, requirement of effective planning for reducing each departments gap and promoting service quality look urgent.
Key words: Perceptions, Dental service, Patient satisfaction, Health care quality assessment, Servqual model, Rafsanjan
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study.
How to cite this article: Ghanbarzadegan A, Iranmanesh F, Amiri S, Esmaeili Nadimi A, Rezaeian M, Bastani P. Situation Analysis of Clinical Performance in Departments of Rafsanjan Dental School Based on Servqual Model in 2016- 2017Academic Year. J Rafsanjan Univ Med Sci 2017; 16(4): 365-80. [Farsi]
Background and Objectives: Diazinon is one of the organophosphorus poisons that is widely used as insecticide and causes male infertility. The aim of this study was to evaluate the effects of broccoli hydroalcholic extract on the changes of the cells of testicular tissue and the control of oxidative stress by diazinon.
Materials and Methods: In this experimental research, 30 adult male Wistar rats weighing 200-250 gr were used. The control group receivied no treatment and the T1 group recievied the peritoneal administration of 30 mg/kg b.w diazinon and the other experimental groups (T2, T3, and T4) received diazonin as well as broccoli extract at dosage of 100, 200, and 300 mg/kg b.w, respectively for 28 days. At the end of the study, the animals were weighed and euthanized. The right testicle was used for histological study and the left testis for measuring malondialdehyde. The data was analyzed using one-way ANOVA and Tukey's post hoc test.
Results: The lowest mean of body weight was 279.763±11.899 gr in the T1 group and the highest was 311.831±8.976 gr in the T4 group and it was observed a statistically significant difference (P=0.038). The number of the sertoli, spermatogonia, spermatocyt, and spermatides cells were 28.751±1.544, 60.501±4.828, 202.503±11.677, and 184.120±19.593, respectively in the T4 group. The highest number avarage was in the T4 group and the lowest in the T1 group (P=0.040). The highiest malondialdehyde concentration was 3.805± 0.017 in the T1 group and the lowest was 2.204± 0.056 µmol/ ml in the T4 group, which was significant (P<0.05).
Conclusion: Broccoli extract at dosage of 300 mg/kg b.w has a positive effect on the spermatogenesis damage caused by diazinon in male rats.
Key words: Oxidative stress, Brassica oleracea var. italica hydroalcholic extract, Diazinon, Testicular tissue, Rat
Funding: This study was funded by Islamic Azad University of Sanandaj Branch.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Sanandaj University approved the study.
How to cite this article: Qaderi Forough M, Raeeszadeh M, Amiri A.A. Dose-Response Changes of Brassica oleracea var. italica Hydroalcholic Extract in the Control of Oxidative Stress by Induction of Diazinon on the Cells of Testicular Tissue in Male Adult Rat. J Rafsanjan Univ Med Sci 2017; 16(7): 593-604. [Farsi]
Multiple sclerosis (MS) is a progressive neurological autoimmune disease that usually starts in the late third and early forth decades of life. Demyelination of neurons in the central nervous system (CNS) and, subsequently, loss of nerve cells is the known disease pathogenesis. The disease is controlled by a class of medicines which are mainly immunomodulators. Fingolimod (FIN) is the first approved oral medication for controlling relapsing-remitting type of MS. It is chemically modified form of a fungus metabolite with long history of use in traditional Chinese medicine. Its mechanism of action is through functional antagonism of sphingosine-1 phosphate receptors which leads to lymphocyte entrapment in lymphoid tissues and reduction of their circulating number in the CNS. FIN efficacy comparing with placebo and first line therapies for MS (e.g. Interferon) has been proved through several clinical trials. Common side effects of FIN are usually mild and are well tolerated. FIN can pass through placenta and has been assigned to pregnancy category C according to the observed effects in animal studies. Since the drug molecule is secreted into milk, lactation during consumption is not recommended.
Considering oral administration and mild side effects of FIN, it can be useful in management of MS. However, due to the incidence of some rare but serious adverse effects such as systemic viral infections, macular edema, and cardiovascular complications, physicians should investigate patient’s clinical status and underlying comorbidities carefully.
Key words: Relapsing-remitting multiple sclerosis, Fingolimod, Sphingosine-1-phosphate receptor modulators
How to cite this article: Amirimoghadam P, Alimardanzadeh A, Sabouri S. Fingolimod; the First Oral Medication for Multiple Sclerosis. J Rafsanjan Univ Med Sci 2018; 17(1): 3-14. [Farsi]
Citation: Amiri M, Mokarami HR, Anoosheh VS, Soltani T, Jabinian Sardehi F. The Effectiveness of Ergonomic Training Interventions Based on the PRECEDE-PROCEED Model on Musculoskeletal Disorders and Stress in Surgical Technologists: Study Protocol for a Randomized Controlled Trial. J Rafsanjan Univ Med Sci 2024; 23 (7): 589-604. [Farsi]
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