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Changes in Blood Pressure and ECG Indices in Males Living Around Ravar, Feyz – Abad Lead Mine
M. Abbasnegad, A. Abbasnegad, A. Afarinesh,
Volume 5, Issue 1 (6-2006)
Abstract

  Changes in Blood Pressure and ECG Indices in Males Living Around Ravar, Feyz – Abad Lead Mine

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  M. Abbasnegad PhD [1] , A. Abbasnegad PhD [2] , A. Afarinesh MSc [3]

 

  Background and Objective: Lead toxicity remains a significant public health problem, since blood levels as low as 10 μg/ml have been shown to cause significant impairment of cardiovascular, cognitive and behavioral functions in human. The objective of this study was to evaluate the effect of lead pollution on cardiovascular function in people living around a lead mine in Ravar.

  Materials and Methods: First the lead concentration in water and plant samples in adiacent areas was measured. Thirty men aged 26±5yr who were living in contaminated areas were selected by a questionnaire (case group), and their blood samples were collected. EKG was performed and records were compared with those of the unexposed control individuals.

  Results: The results showed a high concentration of lead in water, plants and blood samples. The systolic and diastolic blood pressure as well as the heart rate were significantly higher than those of the control group (p<0.05).

  Conclusion: This study indicates that lead compounds in Feyz-Abad area can enter the biological cycle and human body. The high lead levels in exposed subjects can affect the cardiovascular system and alter BP and CR.

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  Key words: Lead, EKG, BP



  [1] - Assistant Professor, Dept. of Biology, Shahid Bahonar University, Kerman

  Corresponding Author Tel: (0341)3220041, Fax: (0341)3222032 E-mail: mabbas@mail.uk.ac.ir

  [2] - Assistant Professor, Dept. of Geology, Shahid Bahonar University, Kerman

  [3] - Academic Member, Dept. of Physiology, Neuroscience Research Center, University of Medical Sciences, Kerman


In Vitro Antioxidant Activity of Pyrus Boissieriana, Diospyros Lotus, Eryngium Caucasicum and Froriepia Subpinnata
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Volume 8, Issue 2 (6-2009)
Abstract

  In Vitro Antioxidant Activity of Pyrus Boissieriana, Diospyros Lotus, Eryngium Caucasicum and Froriepia Subpinnata

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  S.M Nabavi [1] , S.F. Nabavi1, M.A. Ebrahimzadeh [2] , B. Eslami [3]

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  Received: 02/11/08 Sent for Revision: 25/01/09 Received Revised Manuscript: 25/05/09 Accepted: 08/06/09

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  Background and Objectives: Pyrus boissieriana, Diospyros lotus, Eryngium caucasicum, Froriepia subpinnata are native to Northern part of Iran and are widly used in local foods. Diospyros lotus fruits are used in prepration of jams. E.caucasicum and F.subpinnata also used as wild herbs in local foods.

  Materials and Methods: In this Experimental study, the antioxidant activity of methanolic extract of Pyrus boissieriana, Diospyros lotus, Eryngium caucasicum, Froriepia subpinnata were determined with 6 invitro assay include DPPH, nitric oxide, H2O2 radicals scavenging, linoleic acid, reucing power and iron ion chelating activity. Total phenolic and flavonoid compounds of extract was measured by Folin Ciocalteu and AlCl3 assays .

  Results: IC50 in DPPH method was in order : E. caucasicum > F. subpinnata > D. lotus > and P. boissieriana mg ml-1, respectively . The extracts showed weak nitric oxide-scavenging activity. The E. caucasicum and F. subpinnata extracts were better than others respectively. The F. subpinnata and E. caucasicum had shown better reducing power than other extract that was comparable with Vit C (p<0.05).

  Conclusion: F.subpinnata aeial parts and E. caucasicum leaves had higher total phenolic and flavonoid contents than others, which may be the result of higher total phenolic and flavonoid contents of them.

  Keywords: Antioxidant, Eryngium. Caucasicum, Froriepia. Subpinnata, Pyras boissieriana. lotus

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  Funding: This research was funded by a grant from the research council of Mazandaran University of Medical Sciences.

  Conflict of interest: None declared.

  Ethical approval: The Ethics Committee of Mazandaran University of Medical Sciences approved the study .


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  [1] - Researcher, Pharmaceutical Sciences�Research Center, University of Medical Sciences, Mazandaran, Iran

  [2] - Aassociate Prof. Dept of Medicinal Chemistry, Pharmaceutical Sciences�Research Center, University of Medical Sciences, Mazandaran, Iran

  (Corresponding Author) Tel: (0151) 3543081, Fax: (0151) 3543084, E-mail: zadeh20 @yahoo.com

  [3] - Assistante Prof., Dept. of Plant Systematic, Islamic Azad University of Ghaemshahr, Iran


The Effect of Co-administration of Aquous Extract of Bunium Persicum and Endurance Training on Plasma Lipids in Hypercholesterolemic Male Mice
M. Mohammadnia Ahmadi, M. Khaksari Haddad, H. Najafipour, A.r. Saberi Kakhaki, N. Nakhaie, R. Abbasi,
Volume 8, Issue 3 (12-2009)
Abstract

Background and Objectives: The effect of endurance training on lipid profile and cardiovascular endurance in normal rat after Bunium Persicum Extract (BPE) administration has been previously investigated. In the present study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins in hypercholesterolemic male mice was examined.

Material and Methods: In this experimental study, 60 male mice were, randomly, divided into 4 groups: Vehicle, Endurance Training (ET), Bunium Persicum Extract Administer (BPEA) and ET-BPEA group. The Exercise protocol was performed at a speed of 18 m/min, 40 min/day, 5 day/week for 6-weeks. The Bunium Persicum Extract was also administered in the same period and the desired dose (0.8 mg) was reconstituted in 0.4 ml of distilled water. The amount of Triglyceride (TG), Total Cholesterol (TC), HDL-c, LDL-c and Body Weight were registered at the beginning and also at the end of the 6 weeks. Data were analysed using one-way ANOVA method.

Results: The results indicated that the 6-week endurance training accompanied by Bunium Persicum aquous extract administration reduced TC (pretest 297.7±37.08, post test 146.1±30.8, p=0.019) and LDL-c concentrations (pretest 151.8±14.4, post test 0.12±8.7, p=0.001). On the other hand, Bunium Persicum aquous extract administration increased HDL-c concentration significantly (pretest 75.9±12.1, post test 119.9±17.9, p=0.003). Furthermore, the results showed that body weight changes were not significant.

Conclusion: These results suggest that co-administration of BPE and ET could significantly affect plasma lipid and lipoproteins. Therfore performing such program maybe useful for preventing cardiovascular diseases.

Key words: Endurance Training, BPE, Plasma Lipoproteins, Lipids, Mice

 

Funding: This research was funded by Kerman University of Medical Sciences, and Shahid Bahonar University of Kerman.

Conflict of interest: None declared.

gte vml 1]> AWT IMAGEEthical Approval: The Ethical Committee of Kerman University of Medical Sciences approved the study. (Ethical code 85-86 KA)


The Effect of 4 Weeks of High Intensity Interval Training on the Content of AKT1, mTOR, P70S6K1 and 4E-BP1 in Soleus Skeletal Muscle of Rats with Type 2 Diabetes: An Experimental Study
M. Sherafati Moghadam, M. Salesi, F. Daryanoosh, M. Hemati Nafar, A. Fallahi,
Volume 17, Issue 9 (12-2018)
Abstract
Background and Objectives: The most important mechanism of protein synthesis muscle is the mTORC1 pathway in skeletal muscle in which very important proteins play role. Diabetes disturbs this pathway through generating resistance to insulin. The effect of high intensity interval training (HIIT) has not been studied yet on this important pathway in type 2 diabetes. Therefore, the purpose of the present study was to determine the effect of 4 weeks of HIIT on the content of AKT1, mTOR, P70S6K1 and 4E-BP1 proteins in soleus skeletal muscle of rats with type 2 diabetes.
Materials and Methods: In this experimental study, 16 two-month old Sprague-Dawely male rats with an average weight of 260±20 were selected and randomly divided into two groups after being infected to diabetes through STZ induction: diabetic control (n=8) and diabetic training (n=8). The training group exercised 4 weeks (4 days a week) while the control group had no training program. Paired t-test and independent t-test were used to analyze the data.
Results: There was a significant increase in the content of mTOR (p=0.015) and 4E-BP1 (p=0.002) proteins in the training group compared to the control one. However, there was no significant difference in the content of proteins AKT1 (p=0.624) and P70S6K1 (p=0.153) in the two groups. .
Conclusion: Considering the increase in the content of mTOR and 4E-BP1 proteins in soleus skeletal muscle tissue in type 2 diabetic rats, it can be concluded that 4 weeks of HIIT exercise can synthesize protein through mTOR/4E-BP1 pathway.
Key words: High Intensity Interval Training, mTOR, Soleus Skeletal Muscle, Type 2 Diabetes, 4E-BPI, Rat
 
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Shiraz University of Medical Sciences approved the study (IR.SUMS.REC.1396.S1062).
 
How to cite this article: Sherafati Moghadam M, Salesi M, Daryanoosh F, Hemati Nafar M, Fallahi A. The Effect of 4 Weeks of High Intensity Interval Training on the Content of AKT1, mTOR, P70S6K1 and 4E-BP1 in Soleus Skeletal Muscle of Rats with Type 2 Diabetes: An Experimental Study. J Rafsanjan Univ Med Sci 2018; 17 (9): 843-54. [Farsi]
The Effect of Cognitive Behavioral Play Therapy and Its Integration with Parental Management Training on Symptoms of ADHD in 7-11 Year Old Children: A Quasi-Experimental Study
J. Feizollahi, M. Sadeghi, F. Rezaei,
Volume 19, Issue 2 (5-2020)
Abstract
Background and Objectives: Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in childhood. The purpose of this study was to determine and compare the effects of cognitive behavioral play therapy (CBPT) and its integration with parental management training (PMT) on the symptoms of ADHD in children aged 7-11 years.
Materials and Methods: The present study was a quasi-experimental study with pre-test and post-test with the control group. The study population included children with ADHD in Kermanshah city in 2019, of whom 48 were selected by multistage random cluster sampling and they were randomly allocated in experimental groups 1 and 2 and one control group in equal numbers. In the experimental group 1, CBPT was performed in 10 sessions of 10 -90-minute and in the experimental group 2, CBPT and its integration with PMT was performed  in 10 sessions of 10 -90-minute. The control group (group 3) did not receive any intervention. Data were collected before and after the intervention through completing Swanson attention deficit hyperactivity disorder questionnaire. Data were analyzed using multivariate analysis of covariance (MANCOVA).
Results: After the treatment, there was found a statistically significant difference between the average score of the symptoms of ADHD in the experimental group 1 (34.24±1.86) and the control group (37.80±3.23) and the experimental group 2 (31.18±2.07) and the control group (37.80±3.23) (p<0.001). Also, there was a significant difference between the effect of CBPT and the integration of CBPT and PMT (p<0.05). Comparing the mean of two approaches, the integrated intervention was more effective.
Conclusion: CBPT, PMT and their integration might be effective in reducing symptoms of ADHD.  The aforementioned approaches is suggested to be used in psychological counseling centers.
Key words: Cognitive-behavioral play therapy (CBPT), Parent management training (PMT), Attention deficit hyperactivity disorder (ADHD)
 
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Kermanshah University of Medical Sciences approved the study (IR.KUMS.REC.1398.42).
 
How to cite this article: Feizollahi J, Sadeghi M, Rezaei F. The Effect of Cognitive Behavioral Play Therapy and Its Integration with Parental Management Training on Symptoms of ADHD in 7-11 Year Old Children: A Quasi-Experimental Study. J Rafsanjan Univ Med Sci 2020; 19 (2): 155-72. [Farsi]
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