Volume 6, Issue 4 (12-2007)
JRUMS 2007, 6(4): 273-282 |
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The Effects of REM Sleep Deprivation of Pregnant Rats on Spatial Learning of Their Adult Female Offspring. JRUMS 2007; 6 (4) :273-282
URL: http://journal.rums.ac.ir/article-1-5370-en.html
URL: http://journal.rums.ac.ir/article-1-5370-en.html
Abstract: (1746 Views)
Background and Objective: Previous studies have shown that different environmental stresses during pregnancy, affect physiological behaviors of their offspring. In this study the effects of Rapid Eye Movement (REM) sleep deprivation or Paradoxical Sleep Deprivation (PSD) of pregnant rats were studied on the spatial learning of the adult female offspring by Morris water maze (MWM).
Materials and Methods: In this experimental study, flower pot technique was used for PSD. Pregnant rats were divided into 5 groups as follow; group1: in which PSD was performed in 3 days of gestation (E14, E15 and E16) by using small (5.5 cm in diameter) platform. Group2: pregnant rats on large (19 cm in diameter) platform as sham. Group3: Pregnant rats which did not achieved PSD (control). The same treatments were performed on two other groups of pregnant rats in E17, E18 and E19 (group 4 for small platform and group 5 for large platform). The female offspring of all the groups (after maturation in age of 3-3.5 months) were evaluated for MWM.
Results: Offspring of group1 and 2 did not show any significant differences in MWM spatial learning indices when compared with control groups while some of these indices were increased significantly in offspring of group 4 in compared with group 5 and control group (p<0.05).
Conclusion: According to the results, the effects of PSD in pregnant rat on the spatial learning of its adult female offspring rats depend on the duration and the time of the PSD producing various responses.
Key words: REM Sleep Deprivation, Spatial Learning, Pregnant Rat, Morris Water Maze
Funding: This research was jointly funded by: 1-Nouroscience Research Center, University of Medical Sciences, Kerman, Iran. 2- Shahid Bahonar Uniersity Kerman Iran.
Conflict of interest: None declared.
Ethical approval: The Research and Ethics Committee of the Neuroscience Research Center, Kerman University of Medical Science of Iran approved the study.
Materials and Methods: In this experimental study, flower pot technique was used for PSD. Pregnant rats were divided into 5 groups as follow; group1: in which PSD was performed in 3 days of gestation (E14, E15 and E16) by using small (5.5 cm in diameter) platform. Group2: pregnant rats on large (19 cm in diameter) platform as sham. Group3: Pregnant rats which did not achieved PSD (control). The same treatments were performed on two other groups of pregnant rats in E17, E18 and E19 (group 4 for small platform and group 5 for large platform). The female offspring of all the groups (after maturation in age of 3-3.5 months) were evaluated for MWM.
Results: Offspring of group1 and 2 did not show any significant differences in MWM spatial learning indices when compared with control groups while some of these indices were increased significantly in offspring of group 4 in compared with group 5 and control group (p<0.05).
Conclusion: According to the results, the effects of PSD in pregnant rat on the spatial learning of its adult female offspring rats depend on the duration and the time of the PSD producing various responses.
Key words: REM Sleep Deprivation, Spatial Learning, Pregnant Rat, Morris Water Maze
Funding: This research was jointly funded by: 1-Nouroscience Research Center, University of Medical Sciences, Kerman, Iran. 2- Shahid Bahonar Uniersity Kerman Iran.
Conflict of interest: None declared.
Ethical approval: The Research and Ethics Committee of the Neuroscience Research Center, Kerman University of Medical Science of Iran approved the study.
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Type of Study: Research |
Subject:
زيست شناسي
Received: 2020/05/18 | Accepted: 2020/05/18 | Published: 2020/05/18
Received: 2020/05/18 | Accepted: 2020/05/18 | Published: 2020/05/18
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