Volume 19, Issue 10 (1-2021)
JRUMS 2021, 19(10): 1123-1130 |
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Kasaeezadeh F, Asghari-Moghaddam N, Shahla S. The Effect of Crocin on the Expression of MMP-2 and MMP-9 Genes in the Liver Tissue of Cadmium-Treated Rats: A Short Report. JRUMS 2021; 19 (10) :1123-1130
URL: http://journal.rums.ac.ir/article-1-5589-en.html
URL: http://journal.rums.ac.ir/article-1-5589-en.html
Central Tehran Branch, Islamic Azad University
Abstract: (1660 Views)
Background and Objectives: One of the causes of liver cancer is the heavy metal cadmium. Crocin is a compound with antioxidant properties. This study aimed to investigate the effect of crocin on the expression of matrix metalloproteinase 2 and 9 (MMP2 and MMP9) genes in cadmium-induced liver cancer in rats.
Materials and Methods: In this experimental study, 40 female rats were randomly divided into four groups: Control; Crocin (15 mg/kg); Cadmium (20 mg/kg); Crocin±cadmium. After 8 weeks of daily treating by gavage, the liver tissue was removed to evaluate gene expression by Real-Time PCR. Data were analyzed by One-way ANOVA.
Results: The results revealed that cadmium consumption increases the expression of MMP2 and MMP9 genes in the liver tissue (p<0.001). Crocin significantly reduced the expression of both genes in the liver tissue (p<0.001).
Conclusion: Crocin can reduce the raising effect of cadmium on the expression of MMP2 and MMP9 in the liver tissue.
Key words: Liver, Cadmium, Crocin, MMP2, MMP9
Funding: This manuscript did not have any funds
Conflict of interest: None declared
Ethical approval: The Ethics Committee of Tehran Science and Research branch of Islamic Azad University approved the study (IR.IAU.SRB.REC.1397.029)
How to cite this article: Kasaeezadeh F, Asghari-Moghaddam N, Shahla S. The Effect of Crocin on the Expression of MMP-2 and MMP-9 Genes in the Liver Tissue of Cadmium-Treated Rats: A Short Report. J Rafsanjan Univ Med Sci 2021; 19 (10): 1123-30. [Farsi]
Materials and Methods: In this experimental study, 40 female rats were randomly divided into four groups: Control; Crocin (15 mg/kg); Cadmium (20 mg/kg); Crocin±cadmium. After 8 weeks of daily treating by gavage, the liver tissue was removed to evaluate gene expression by Real-Time PCR. Data were analyzed by One-way ANOVA.
Results: The results revealed that cadmium consumption increases the expression of MMP2 and MMP9 genes in the liver tissue (p<0.001). Crocin significantly reduced the expression of both genes in the liver tissue (p<0.001).
Conclusion: Crocin can reduce the raising effect of cadmium on the expression of MMP2 and MMP9 in the liver tissue.
Key words: Liver, Cadmium, Crocin, MMP2, MMP9
Funding: This manuscript did not have any funds
Conflict of interest: None declared
Ethical approval: The Ethics Committee of Tehran Science and Research branch of Islamic Azad University approved the study (IR.IAU.SRB.REC.1397.029)
How to cite this article: Kasaeezadeh F, Asghari-Moghaddam N, Shahla S. The Effect of Crocin on the Expression of MMP-2 and MMP-9 Genes in the Liver Tissue of Cadmium-Treated Rats: A Short Report. J Rafsanjan Univ Med Sci 2021; 19 (10): 1123-30. [Farsi]
Type of Study: Research |
Subject:
زيست شناسي
Received: 2020/09/15 | Accepted: 2020/11/4 | Published: 2021/01/21
Received: 2020/09/15 | Accepted: 2020/11/4 | Published: 2021/01/21
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