Volume 23, Issue 11 (3-2025)
JRUMS 2025, 23(11): 1037-1043 |
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Kaeidi A. Memory Impairment and Hippocampal Damage after Repeated Morphine Use:
A Point of View. JRUMS 2025; 23 (11) :1037-1043
URL: http://journal.rums.ac.ir/article-1-7604-en.html
URL: http://journal.rums.ac.ir/article-1-7604-en.html
Rafsanjan University of Medical Sciences
Abstract: (256 Views)
The hippocampus, as one of the key structures of the brain, plays a crucial role in cognitive processes such as memory formation and information storage. Morphine administration can cause significant changes in the structure and function of the hippocampus, which has raised concerns about its long-term effects on cognitive health. Morphine acts mainly through the activation of opioid receptors in the central nervous system, and this activation can lead to oxidative stress, neuroinflammation, and neuronal apoptosis. Changes in dendritic density and morphology of hippocampal neurons lead to reduced synaptic plasticity, which in turn can impair cognitive functions such as learning and memory. The cumulative effects of oxidative stress, inflammation, and synaptic changes lead to cognitive impairments such as deficits in spatial memory and learning abilities. Therefore, understanding the underlying mechanisms of morphine's neurotoxic effects on the hippocampus is essential for the development of therapeutic interventions. The best treatment solution is to make people aware and prevent it.
Key words: Morphine, Hippocampus, Memory
Funding: None.
Conflict of interest: Not applicable.
Ethical considerations: Not applicable.
Authors’ contributions:
- Conceptualization: Ayat Kaeidi
- Methodology: Ayat Kaeidi
- Data collection: Ayat Kaeidi
- Formal analysis: Ayat Kaeidi
- Supervision: Ayat Kaeidi
- Project administration: Ayat Kaeidi
- Writing - original draft: Ayat Kaeidi
- Writing - review & editing: Ayat Kaeidi
Citation: Kaeidi A. Memory Impairment and Hippocampal Damage After Repeated Morphine Use: A Point of View. J Rafsanjan Univ Med Sci 2025; 23 (11): 1037-43. [Farsi]
Key words: Morphine, Hippocampus, Memory
Funding: None.
Conflict of interest: Not applicable.
Ethical considerations: Not applicable.
Authors’ contributions:
- Conceptualization: Ayat Kaeidi
- Methodology: Ayat Kaeidi
- Data collection: Ayat Kaeidi
- Formal analysis: Ayat Kaeidi
- Supervision: Ayat Kaeidi
- Project administration: Ayat Kaeidi
- Writing - original draft: Ayat Kaeidi
- Writing - review & editing: Ayat Kaeidi
Citation: Kaeidi A. Memory Impairment and Hippocampal Damage After Repeated Morphine Use: A Point of View. J Rafsanjan Univ Med Sci 2025; 23 (11): 1037-43. [Farsi]
Type of Study: Research |
Subject:
Physiology
Received: 2024/12/24 | Accepted: 2025/01/22 | Published: 2025/03/20
Received: 2024/12/24 | Accepted: 2025/01/22 | Published: 2025/03/20
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