مجله علمی دانشگاه علوم پزشکی رفسنجان
جلد 25، شماره 5 - ( 8-1405 )
جلد 25 شماره 5 صفحات 572-549 |
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Abdulhamza Azeez Al-Agele B, Seifi-asgshahr F, Farzizadeh R. Investigating the Time-Dependent Responses of Mitochondrial and Antioxidant Systems to Exercise Training in Animal Models: A Systematic Review and Meta-Analysis. , JRUMS. 2026; 25 (5) :549-572
URL: http://journal.rums.ac.ir/article-1-7964-fa.html
URL: http://journal.rums.ac.ir/article-1-7964-fa.html
عبدالحمزه عزیز ال‌عقیلی بلیل، سیفی اسکی شهر فرناز، فرضی زاده رضا. بررسی وابستگی زمانی پاسخ‌های میتوکندری و آنتی‌اکسیدانی به تمرین ورزشی در مدل‌های حیوانی: یک مرور نظام‌مند و فراتحلیل. , مجله دانشگاه علوم پزشکی رفسنجان. 1405; 25 (5) :549-572
دانشگاه محقق اردبیلی
چکیده: (36 مشاهده)
زمینه و هدف: تمرین ورزشی موجب بیوژنز میتوکندری و سازگاری‌های ردوکس سلولی می‌شود. هدف از مطالعه مروری حاضر، تعیین سازگاری‌های میتوکندریایی و ردوکس سلولی وابسته به زمان در پاسخ به تمرین ورزشی در مدل‌های پیش‌بالینی میباشد.
مواد و روش‌ها: در این مرور نظام‌مند و فراتحلیل، جستجوی نظام‌مند در پایگاه‌های PubMed، Scopus و Web of Science برای مطالعات منتشر شده از ژانویه 2000 تا دسامبر 2025 انجام شد. مطالعات پیش‌بالینی که به ارزیابی پیامدهای میتوکندریایی (شامل گیرنده فعال کننده تکثیر پروکسیزوم گاما 1 آلفا (PGC‑1α) و میتوفوسین‑۱ (Mfn‑1)) و پیامدهای ردوکس سلولی (شامل فاکتور هسته‌ای اریتروئید ۲ مرتبط با فاکتور ۲ (Nrf2)، سوپراکسید دیسموتاز (SOD)، گلوتاتیون پراکسیداز (GPx)، گونه‌های فعال اکسیژن (ROS) و مالون‌دی‌آلدئید (MDA)) پرداخته بودند، وارد مطالعه شدند. فراتحلیل با مدل اثرات تصادفی انجام گرفت و ناهمگنی با تحلیل زیرگروه بر اساس مدت مداخله ارزیابی شد.
یافته‌ها: از ۴۹۷ رکورد شناسایی‌شده، 41 مطالعه برای مرور نظام‌مند و 27 مطالعه برای فراتحلیل انتخاب شدند. تمرین ورزشی باعث افزایش معنادار PGC-1α (001/0=P)، Nrf2 (001/0>P) و GPx (003/0=P) شد. در مقابل، SOD و نیز ROS، Mfn-1 و MDA از نظر آماری معنادار نبودند (05/0<P). تحلیل زیرگروه نشان داد که مداخلات کوتاه‌مدت (کمتر از 5 هفته)، با فعال‌سازی قوی‌تر SOD، GPx، PGC-1α و Nrf2 همراه بودند، در حالی‌که پروتکل‌های بلند مدت (بیش از 5 هفته) پاسخ‌های ضعیف‌تری نشان دادند. در تمامی پیامدها ناهمگنی بالای 72% مشاهده شد.
نتیجه‌گیری: به‌نظر می‌رسد تمرین ورزشی به‌عنوان یک محرک Hormesis در مدل‌های پیش‌بالینی، عمدتاً تنظیم‌کننده‌های بالادستی را فعال می‌کند. این پاسخ‌های زمان‌وابسته، احتمالاً از سیگنال‌دهی اولیه تا پایداری هموستاتیک را شامل می‌شوند.
واژه‌های کلیدی: تمرین ورزشی، بیوژنز میتوکندریایی، استرس اکسیداتیو، PGC‑1α، Nrf2، فراتحلیل
مواد و روش‌ها: در این مرور نظام‌مند و فراتحلیل، جستجوی نظام‌مند در پایگاه‌های PubMed، Scopus و Web of Science برای مطالعات منتشر شده از ژانویه 2000 تا دسامبر 2025 انجام شد. مطالعات پیش‌بالینی که به ارزیابی پیامدهای میتوکندریایی (شامل گیرنده فعال کننده تکثیر پروکسیزوم گاما 1 آلفا (PGC‑1α) و میتوفوسین‑۱ (Mfn‑1)) و پیامدهای ردوکس سلولی (شامل فاکتور هسته‌ای اریتروئید ۲ مرتبط با فاکتور ۲ (Nrf2)، سوپراکسید دیسموتاز (SOD)، گلوتاتیون پراکسیداز (GPx)، گونه‌های فعال اکسیژن (ROS) و مالون‌دی‌آلدئید (MDA)) پرداخته بودند، وارد مطالعه شدند. فراتحلیل با مدل اثرات تصادفی انجام گرفت و ناهمگنی با تحلیل زیرگروه بر اساس مدت مداخله ارزیابی شد.
یافته‌ها: از ۴۹۷ رکورد شناسایی‌شده، 41 مطالعه برای مرور نظام‌مند و 27 مطالعه برای فراتحلیل انتخاب شدند. تمرین ورزشی باعث افزایش معنادار PGC-1α (001/0=P)، Nrf2 (001/0>P) و GPx (003/0=P) شد. در مقابل، SOD و نیز ROS، Mfn-1 و MDA از نظر آماری معنادار نبودند (05/0<P). تحلیل زیرگروه نشان داد که مداخلات کوتاه‌مدت (کمتر از 5 هفته)، با فعال‌سازی قوی‌تر SOD، GPx، PGC-1α و Nrf2 همراه بودند، در حالی‌که پروتکل‌های بلند مدت (بیش از 5 هفته) پاسخ‌های ضعیف‌تری نشان دادند. در تمامی پیامدها ناهمگنی بالای 72% مشاهده شد.
نتیجه‌گیری: به‌نظر می‌رسد تمرین ورزشی به‌عنوان یک محرک Hormesis در مدل‌های پیش‌بالینی، عمدتاً تنظیم‌کننده‌های بالادستی را فعال می‌کند. این پاسخ‌های زمان‌وابسته، احتمالاً از سیگنال‌دهی اولیه تا پایداری هموستاتیک را شامل می‌شوند.
واژه‌های کلیدی: تمرین ورزشی، بیوژنز میتوکندریایی، استرس اکسیداتیو، PGC‑1α، Nrf2، فراتحلیل
نوع مطالعه: مقاله مروري |
موضوع مقاله:
فيزيولوژي
دریافت: 1405/1/28 | پذیرش: 1405/6/31 | انتشار: 1405/8/28
دریافت: 1405/1/28 | پذیرش: 1405/6/31 | انتشار: 1405/8/28
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