Journal of Rafsanjan University of Medical Sciences

The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report

S. Rasaneh[1], F. Johari-Daha[2]

Received: 27/07/2014      Sent for Revision: 23/08/2014      Received Revised Manuscript: 20/09/2014     Accepted: 06/10/2014

Background and Objective: In nuclear medicine, lung perfusion scintigraphy is performed by radiolabeled particles, 99 mTc-albumin macroaggregated. Synthesizing of the particles has some difficulties. In order to resolve this problem, chitosan microparticles were used as an alternative choice.

Materials and Methods: The qualitative control tests including: the determining particles size, the labeling efficiency and stability in saline buffer and imaging studies in the mice were performed.

Results: The size of particles was 90-110 micron. The labeling efficiency was 94±3%, the good stability in saline buffer and high accumulation of activity in mice lung were seen.

Conclusion: The results showed that the 99mTc-chitosan microparticles may be considered as a promising radiopharmaceutical of lung perfusion scintigraphy that needs more investigations.

Key words: Chitosan, Lung perfusion scintigraphy, 99mTc-albumin macroaggregated, 99mTc

Funding: This research was not funded by any university or organization.

Conflict of Interest: Not declared.

Ethical approval: This research was performed based on the Ethics Committee of Nuclear science and Technology institute, Helsinki ethic.

How to cite this article: Rasaneh S, Johari-Daha F. The Application of 99mTc-Chitosan Microparticles in Lung Imaging of Mice: A Short Report. J RafsanjanUniv Med Sci 2015; 13(10): 1013-18. [Farsi]