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Background and Objective: In nuclear medicine, lung perfusion
scintigraphy is performed by radiolabeled particles, 99 mTc-albumin macroaggregated.
Synthesizing of the particles has some difficulties. In order to resolve this
problem, chitosan microparticles were used as an alternative choice.
Materials
and Methods: The
qualitative control tests including: the determining particles size, the
labeling efficiency and stability in saline buffer and imaging studies in the
mice were performed.
Results: The size of particles was 90-110
micron. The labeling efficiency was 94±3%, the good stability in saline buffer
and high accumulation of activity in mice lung were seen.
Conclusion: The results showed that the 99mTc-chitosan microparticles may
be considered as a promising radiopharmaceutical of lung perfusion scintigraphy
that needs more investigations.
Key
words: Chitosan, Lung perfusion scintigraphy, 99mTc-albumin macroaggregated, 99mTc
Funding: This research
was not funded by any university or organization.
Conflict of Interest: Not declared.
Ethical approval: This research
was performed based on the Ethics Committee of Nuclear science
and Technology institute, Helsinki ethic.
How to cite this article:
Rasaneh S, Johari-Daha F. The Application of 99mTc-Chitosan
Microparticles in Lung Imaging of Mice: A Short Report. J RafsanjanUniv Med Sci 2015 13(10): 1013-18. [Farsi]
Received: 2014/07/16 | Accepted: 2015/02/25 | Published: 2015/02/25
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