Volume 3, Issue 1 (12-2004)
JRUMS 2004, 3(1): 17-24 |
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Biochemical and Hematological Alterations in Vivax Malaria in Kahnouj City. JRUMS 2004; 3 (1) :17-24
URL: http://journal.rums.ac.ir/article-1-5417-en.html
URL: http://journal.rums.ac.ir/article-1-5417-en.html
Abstract: (2078 Views)
Background: Malaria pathogenesis is based mainly on extensive changes of biochemical and hematological parameters. The normal values of these parameters differ according to ethnic, racial and economic conditions, and there was no study on them in Iran. The aim of this study was the survey of hematological and biochemical parameters in acute stage of vivax malaria. Regarding to restoration of these altered parameters to normal levels after treatment, we can attributed the changes to effects of malaria disease on human body and can apply them in malaria diagnosis and treatment as well as understanding the malaria pathogenesis.
Materials and Methods: This study was carried out on 70 male patients infected to Plasmodium vivax living in Kahnouj city. Serum levels of total and direct bilirubin, total protein and cholesterol, transaminases (SGOT, SGPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) as well as hemoglobin (Hb), hematocrit (Hct), RBC count and RBC indices ( MCV and MCH) of the patients were measured before and after radical treatment with chloroquine and primaquine. Then, differences between of the mean pre- and post-treatment levels of these parameters as well as correlation between the parameters and ages of the patient were statistically analyzed.
Results: Post-treatment levels of protein, albumin, cholesterol, Hb, Hct, RBC count and MCV were significantly increased (p<0.001). In contrast, post-treatment serum levels of total and direct bilirubin, transaminases, ALP, LDH as well as MCH significantly decreased (p<0.001). Among mentioned parameters, changes of serum levels of direct bilirubin, cholesterol and ALP had a significant but reverse correlation to ages of patients.
Conclusion: Patterns of some biochemical and hematological alterations specially cholesterol, ALP and direct bilirubin are useful as indices in determining the severity of malaria disease in patients infected to plasmodium vivax.
Key words: Malaria, Plasmodium vivax, Biochemical and Hematological alterations.
Materials and Methods: This study was carried out on 70 male patients infected to Plasmodium vivax living in Kahnouj city. Serum levels of total and direct bilirubin, total protein and cholesterol, transaminases (SGOT, SGPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) as well as hemoglobin (Hb), hematocrit (Hct), RBC count and RBC indices ( MCV and MCH) of the patients were measured before and after radical treatment with chloroquine and primaquine. Then, differences between of the mean pre- and post-treatment levels of these parameters as well as correlation between the parameters and ages of the patient were statistically analyzed.
Results: Post-treatment levels of protein, albumin, cholesterol, Hb, Hct, RBC count and MCV were significantly increased (p<0.001). In contrast, post-treatment serum levels of total and direct bilirubin, transaminases, ALP, LDH as well as MCH significantly decreased (p<0.001). Among mentioned parameters, changes of serum levels of direct bilirubin, cholesterol and ALP had a significant but reverse correlation to ages of patients.
Conclusion: Patterns of some biochemical and hematological alterations specially cholesterol, ALP and direct bilirubin are useful as indices in determining the severity of malaria disease in patients infected to plasmodium vivax.
Key words: Malaria, Plasmodium vivax, Biochemical and Hematological alterations.
Type of Study: Research |
Subject:
Parasitology
Received: 2020/06/8 | Accepted: 2020/06/8 | Published: 2020/06/8
Received: 2020/06/8 | Accepted: 2020/06/8 | Published: 2020/06/8
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