Journal of Rafsanjan University of Medical Sciences

  Background and Objective: Microbial biofilms are responsible for 65% of human infections, and are resistance to antibiotics. Pseudomonas aeruginosa is one of the most important biofilm producing bacteria. This review tries to explain the last mechanisms of Pseudomonas aeruginosa biofilm formation, the reasons for its resistance to antimicrobial agents, as well as new preventive measures and anti- biofilms agents.

  Materials and Methods: In this review article, the information resources including Pub Med, Daneshyar network, DOAJ, ProQuest, Ovid, Elsevier Sciences, Google Scholar , and Integrated Digital Library were searched using pseudomonas biofilm, anti- biofilm and biofilm treatment as the key words.

  Results : R outine antimicrobial treatments fail to eradicate biofilms. Because of the distinctive properties of biofilm, it requires a different treatment. Biofilms are important in drug resistance, therefore scientists are exploring appropriate ways to control and prevent biofilm formation .

  Conclusion : In conclusion, surface modification and physical methods are techniques that prevent biofilm formation . Due to resistance of biofilm to current antibiotics , various unconventional treatments have been reported from around the world .

  Key words: Biofilm, Pseudomonas aeruginosa, Anti- Biofilm agents

  Funding: This study did not have any supported.

  Conflict of interest: . None declared

  How to cite this article : Ghotaslou R, Salahi Eshlaqghi B. Biofilm of Pseudomonas Aeruginosa and New Preventive Measures and Anti- Biofilm Agents . J Rafsanjan Univ Med Sc i 2013 12(9): 747-68. [Farsi]