Journal of Rafsanjan University of Medical Sciences

  Background and Objectives: Central giant cell granuloma formerly called "giant cell reparative granuloma," is a non-neoplastic lesion. Some lesions demonstrate aggressive behaviors similar to that of a neoplasm . The mandibular / maxillary ratio has been reported as being from 2:1 to 3:1. Lesions are more common in the anterior portions of the jaws

  Results: An 11-year old girl was referred with a chief complaint of chin expansion without pain. The radiographic exam ination showed a multilocular radiolucent lesion extended to lower border of the mandible. The histopathological examination showed a highly vascularized fibrous stroma with several multinucleated giant cells. Because of size of lesion, surgical approach was preferred .

  Conclusion: Most giant cell granulomas of the jaws are asymptomatic and usually first come to attention during a routine radiographic examination or as a result of painless expansion of the affected bone. So early diagnosis is very important in the prognosis.

  Key words: Giant Cell Granuloma, Giant Cell , Reparative Giant Cell Granuloma

  Funding: This research was funded by Rafsanjan University of Medical Sciences.

  Conflict of interest: None declared.

  Ethical approval: The Ethics Committe of Rafsanjan University of Medical Sciences approved this study .

  How to cite this article : Khoramian S, Poureslami HR , Torabi M, Mohammadi B. Central Giant cell Granuloma: A Case Report . J Rafsanjan Univ Med Scie 2012 11(5): 489-96. [Farsi]