Journal of Rafsanjan University of Medical Sciences

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Background and Objectives:  Currently, Escherichia coli is considered as one of the main causes of bacterial urinary tract infections. The aim of this study was evaluating the frequency of necrotizing factor type 1 (CNF1) and hemolysin (Hly) genes among E. coli strains isolated from hospitalized patients of Rouhani Hospital in Babol city.
Materials and Methods: In this descriptive study, a total of 82 E. coli strains were evaluated. Thereafter, antibiogram test was performed and DNA of the bacteria was extracted and the frequency of CNF1 and Hly genes was determined by the help of polymerase chain reaction.
Results: With antibiotic susceptibility testing, resistance to Erythromycin and Imipenem was reported 59 (71.9%)  and 0%, respectively. Also, the percentage of multi drug resistant strains was 31.7%. The frequency of CNF1 and Hly genes was reported as 28% and 32.9%, respectively.
Conclusion: According to the results, the frequency of CNF1 and Hly genes among the studied strains was similar to some related studies.
Key words: Escherichia coli, Urinary tract infections, Polymerase chain reaction
 
Funding: This study was funded by a grant (no. 3870) from the Research Council of Babol University of Medical Sciences.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Babol University of Medical Sciences approved the study (MUBABOL.HRI.REC.1395.248).
 
How to cite this article: Shabani A, Amini A, Ebrahimzadeh Namvar A. Frequency of Necrotizing Factor Type 1 and Hemolysin Genes Among Escherichia coli Strains Isolated from Hospitalized Patients of Rouhani Hospital in Babol, IRAN in 2017: A Short Report. J Rafsanjan Univ Med Sci 2018; 17 (7): 681-8. [Farsi]
 
 

Keywords: Escherichia coli, Urinary tract infections, Polymerase chain reaction

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