Journal of Rafsanjan University of Medical Sciences

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Background and Objectives: Despite the widespread availability of antibiotics, antibiotic resistance in uropathogens is increasing. The most common mechanism in the antibiotic resistance is production of extended spectrum B-lactamase (ESBL). In this study, the presence of producing ESBL among isolated Escherchia Coli from patients suffering from urinary tract infections in Ali-Ebne Abitaleb hospital (Rafsanjan, Iran) as well as their sensitivity to newer antibiotics were evaluated.
Material and methods: In this descriptive study, 146 Escherchia Coli were collected from 1634 urine samples of suspected patients with urinary tract infection. Isolated organisms were identified by standard biochemical and microbial tests. Antibiotic susceptibility test was done by disc diffusion method. Isolated E coli that were resistant to third generation cephalosporines were tested for ESBL phenotype by double disc synergy test method. Their susceptibility to imipenem, meropenem and cefepime were also determined.
Results: Totally, 19.86% of the isolated E coli showed resistance to third generation cephalosporines and 10.27% of them were ESBL producer. Also ESBLs E Coli showed co-resistance to other antibiotics. Susceptibility to imipenem, meropenem were 100%, and cefepime 26.66% respectively.
Conclusion: ESBL producer isolated Escherchia Coli had resistance to many different antibiotics, but it showed high susceptibility to imipenem and meropenem. So in order to prevent any resistance, we should use these antibiotics correctly.
Key words: Extended Spectrum B-lactamase(ESBL), Escherchia Coli, Urinary Infection
 
Funding: This research was funded by Research Council of Rafsanjan University of Medical Sciences.
Conflict of interest: None declared.
Ethical Approval: The Ethics Committee of Rafsanjan University of Medical Sciences, approved the study.
 
How to cite this article: Tashkori M, Farokhnia M, Zia Sheikhaleslami N, Mirzaei T, Yosefi H, Mokhtari F, Mohyadini A. Evaluation of Producing Extended Spectrum β-lactamase among Isolated Escherchia Coli from Patients Suffering from Urinary Tract Infections: (Short Report). J Rafsanjan Univ Med Sci 2011; 10(1): 62-68. [Farsi]

Keywords: Extended Spectrum B-lactamase(ESBL), Escherchia Coli, Urinary Infection

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