Volume 20, Issue 1 (4-2021)                   JRUMS 2021, 20(1): 119-128 | Back to browse issues page

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nowzari V, zare A. Improvement of Spatial Memory Impairment Following Voluntary Exercise in Morphine-Dependent Rats: A Short Report. JRUMS 2021; 20 (1) :119-128
URL: http://journal.rums.ac.ir/article-1-5660-en.html
Lecturer at Farhangian University
Abstract:   (1038 Views)
Background and Objectives: Exercise is one way to treat addiction. The aim of this study was to determine the improvement of spatial memory impairment following voluntary exercise in morphine-dependent rats.
Materials and Methods: In this experimental study, the sample rats received morphine (10 mg/kg) twice a day, 12 hours subcutaneously, at the same time as 10 days of running. All rats were then trained for 5 consecutive days and twice daily in the Mauritius water maze. Analysis of variance and Tukey’s test were used to analyze the data.
Results: Comparison between groups showed that morphine-dependent and athletic control groups spent significantly more time in the target area than morphine-dependent and non-exercised control groups (respectively p=0.04 and p=0.0001) and this indicates that exercise improved spatial memory recall.
Conclusion: Voluntary exercise might be considered as a potential method to ameliorate some of the deleterious behavioral consequences of morphine abuse.
Key words: Morphine dependency, Voluntary exercise, Morris water maze, Rat
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Research Committee of Islamic Azad University, Yasouj Branch approved the study (Thesis code 12021404942033).
How to cite this article: Nowzari V, Zare A. Improvement of Spatial Memory Impairment Following Voluntary Exercise in Morphine-Dependent Rats: A Short Report. J Rafsanjan Univ Med Sci 2021; 20 (1): 125-34. [Farsi]
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Type of Study: Short Report | Subject: تربيت بدني
Received: 2020/11/1 | Accepted: 2021/01/26 | Published: 2021/04/21

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