Volume 20, Issue 3 (6-2021)                   JRUMS 2021, 20(3): 313-324 | Back to browse issues page


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Shahrabadi E, Bakhshi Aliabad H, Mirani Roudbari M, Mirzaee V. Comparison of Effectiveness of Minimum and Maximum Dose of Pantoprazole in the Treatment of Patients with Hemorrhagic Gastric Ulcer Referred to Ali-Ebn Abitaleb Hospital in Rafsanjan in 2016-2017: A Randomized Clinical Trial. JRUMS 2021; 20 (3) :313-324
URL: http://journal.rums.ac.ir/article-1-5725-en.html
Abstract:   (1555 Views)
Background and Objectives: Proton pump inhibitors (PPIs) have an important role in stabilizing clots caused by upper gastrointestinal bleeding. The aim of this study was performed to compare and determine the effectiveness of the minimum and maximum dose of pantoprazole in the treatment of patients with hemorrhagic gastric peptic ulcer, referred to Rafsanjan Ali ebn Abitaleb Hospital.
Materials and Methods: This randomized clinical trial was performed on 104 patients with upper gastrointestinal bleeding in Rafsanjan Ali ebn Abitaleb Hospital in 2016-2017. Patients were randomly divided into two equal groups. Group A was given a high dose of pantoprazole (80 mg) and group B was given a low dose (40 mg). For gender and age matching, the two groups were compared (p>0.05). Data were analyzed using descriptive statistics (frequency, percentage, mean and standard deviation) and inferential statistics (independent t-test, chi-square test or Fisher's exact test). 
Results: The mean and standard deviation of patients' age in group A were 52.96±22.79 years and in group B 52.51± 23.18 years (p=0.921). No significant difference was observed between the sexes in the two groups (p=0.823). PPI dose was not significantly associated with mortality rate, hemorrhage, hospitalization days, drop in hemoglobin, need for surgery (p>0.05).
Conclusion: In this study, the efficacy of high-dose pantoprazole compared with low-dose in clinical outcomes including mortality, need for surgery, hemorrhage, number of hospitalization days, and hemoglobin drop did not differ between the two groups. Therefore, for the health of patients at the optimal dose, clinical studies with a larger sample size are recommended.
Key words: Pantoprazole, Hemorrhagic gastric ulcer, Upper gastrointestinal bleeding, Peptic ulcer
 
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study (IR.RUMS.REC.1394.246).
 
How to cite this article: Shahrabadi E, Bakhshi H, Mirani Roudbari M, Mirzaei V. Comparison of Effectiveness of Minimum and Maximum Dose of Pantoprazole in the Treatment of Patients with Hemorrhagic Gastric Ulcer Referred to Ali-Ebn Abitaleb Hospital in Rafsanjan in 2016-2017: A Randomized Clinical Trial. J Rafsanjan Univ Med Sci 2021; 20 (3): 313-24. [Farsi]
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Type of Study: Research | Subject: Internal Medicine
Received: 2020/12/6 | Accepted: 2021/05/9 | Published: 2021/06/20

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