Volume 20, Issue 8 (11-2021)
JRUMS 2021, 20(8): 879-890 |
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Tamjid M, Mahmoudi F, Abdolmaleki A, Mirzaee S. Preparation of Omega-3 Coated Iron Oxide Nanoparticles and Their Effect on Hepatic, Renal, and Splenic Function in Rats: An Experimental Study. JRUMS 2021; 20 (8) :879-890
URL: http://journal.rums.ac.ir/article-1-6095-en.html
URL: http://journal.rums.ac.ir/article-1-6095-en.html
1. Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran. 2. Bio Science and Biotechnology Research center (BBRC), Sabalan University of Advanced Technologies (SUAT), Namin, Iran.
Abstract: (1685 Views)
Background and Objectives: Due to its unique properties, iron oxide nanoparticles have many applications in medicine. The aim of this study was to prepare omega-3 coated iron oxide nanoparticles and investigate their effect on liver and kidney, and spleen function in rats.
Materials and Methods: In this experimental study, 30 Wistar rats were randomly divided into three groups including control group (receiving physiology serum as drug solvent), experimental groups 1 and 2 treated with omega-3 coated iron oxide nanoparticles with doses of 10 and 30 mg/kg, respectively. After one week of drug treatment, blood sampling and tissue sampling of liver, kidney, and spleen were performed. One-way analysis of variance, Tukey’s post hoc, Levene, and non-parametric Kolmogorov-Smirnov tests were used for data analysis.
Results: Injection of nanoparticles at a dose of 10 mg/kg did not show a significant change in blood urea and AST (Aspartate Transaminase) factors compared to the control group (p=0.042). However, at a dose of 30 mg/kg, creatinine and ALT (Alanine Transaminase) blood factors increased significantly compared to the control group (p =0.038). Histopathological examination of liver, kidney, and spleen tissue samples of the treated groups did not show any tissue disorders compared to the control group.
Conclusion: The results showed that omega-3 coated iron oxide nanoparticles at low doses had no toxic effects on the studied tissues and did not disrupt blood factors. Therefore, it can be further evaluated as an adjunct in the treatment of cancer cells as well as drug carriers.
Key words: Iron oxide nanoparticles, Liver, Kidney, Histotoxicity, Rat
Funding: This study was funded by University of Mohaghegh Ardabili.
Conflict of interest: The authors declare that they have no conflicts of interest.
Ethical approval: The Ethics Committee of University of Mohaghegh Ardabili approved the study (IR.ARUMS.REC.1400.08).
How to cite this article: Tamjid M, Mahmoudi F, Abdolmaleki A, Mirzaee Sh. Preparation of Omega-3 Coated Iron Oxide Nanoparticles and Their Effect on Hepatic, Renal, and Splenic Function in Rats: An Experimental Study. J Rafsanjan Univ Med Sci 2021; 20 (8): 879-90. [Farsi]
Materials and Methods: In this experimental study, 30 Wistar rats were randomly divided into three groups including control group (receiving physiology serum as drug solvent), experimental groups 1 and 2 treated with omega-3 coated iron oxide nanoparticles with doses of 10 and 30 mg/kg, respectively. After one week of drug treatment, blood sampling and tissue sampling of liver, kidney, and spleen were performed. One-way analysis of variance, Tukey’s post hoc, Levene, and non-parametric Kolmogorov-Smirnov tests were used for data analysis.
Results: Injection of nanoparticles at a dose of 10 mg/kg did not show a significant change in blood urea and AST (Aspartate Transaminase) factors compared to the control group (p=0.042). However, at a dose of 30 mg/kg, creatinine and ALT (Alanine Transaminase) blood factors increased significantly compared to the control group (p =0.038). Histopathological examination of liver, kidney, and spleen tissue samples of the treated groups did not show any tissue disorders compared to the control group.
Conclusion: The results showed that omega-3 coated iron oxide nanoparticles at low doses had no toxic effects on the studied tissues and did not disrupt blood factors. Therefore, it can be further evaluated as an adjunct in the treatment of cancer cells as well as drug carriers.
Key words: Iron oxide nanoparticles, Liver, Kidney, Histotoxicity, Rat
Funding: This study was funded by University of Mohaghegh Ardabili.
Conflict of interest: The authors declare that they have no conflicts of interest.
Ethical approval: The Ethics Committee of University of Mohaghegh Ardabili approved the study (IR.ARUMS.REC.1400.08).
How to cite this article: Tamjid M, Mahmoudi F, Abdolmaleki A, Mirzaee Sh. Preparation of Omega-3 Coated Iron Oxide Nanoparticles and Their Effect on Hepatic, Renal, and Splenic Function in Rats: An Experimental Study. J Rafsanjan Univ Med Sci 2021; 20 (8): 879-90. [Farsi]
Type of Study: Research |
Subject:
زيست شناسي
Received: 2021/07/12 | Accepted: 2021/09/20 | Published: 2021/11/19
Received: 2021/07/12 | Accepted: 2021/09/20 | Published: 2021/11/19
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