Volume 2, Issue 3 And 3-4 (9-2003)                   JRUMS 2003, 2(3 And 3-4): 124-130 | Back to browse issues page

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Gol A, Sofiabadi M, Abbasnejad M, Parvizi M. The Regulatory Effect of Female Sex Steroid Hormones on Nitric Oxid Production. JRUMS. 2003; 2 (3 and 3-4) :124-130
URL: http://journal.rums.ac.ir/article-1-61-en.html
Abstract:   (16592 Views)
The Regulatory Effect of Female Sex Steroid Hormones on Nitric Oxid Production


  A.Gol*1 Ph.D, M.Sofiabadi2 Ph.D, M.Abbasnejad3 Ph.D, MR. Parvizi4 MSc


  1- Assistant professor,Dept.of Physiology,Univ.of Oromie Medical Sciences,Oromie,Iran

  2- Assistant professor,Dept.of Physiology,Univ.of Qazvin Medical Sciences,Qazvin,Iran

  3- Assistant professor,Dept.of Physiology,Univ.of Kerman Medical Sciences,Kerman,Iran

  4- Instructor,Dept.of Physiology,Univ.of Qazvin Medical Sciences,Qazvin,Iran



  Background: Nitric oxide production in body regulates moltifactorial and sex steroid hormones may be have a role on this process.The role of estrogen and progesterone on nitric oxide production not fully understood and the aim of this study was to detect the effect of ovarin steroid hormones on nitric oxide production in female rats.

  Materials and Methods: 120 female rats ovarectomized and 14 days after surgery they divided to 3 groups: Estrogen group received estradiol benzoat (10µg/kgw/sc) and progesterone group that received progestrone (25 mg/kgw/sc) and last group received both hormones ( progestrone 25 mg/kgw/sc and estradiol benzoat 10µg/kgw/sc) , also each group received l-name (60 mg/kgw/ip) and l-arginine(100 mg/kgw/ip) or vehicle .6 hours after treatment, blood samples prepared and nitrite - nitrate of serums measured with griess reaction method.

  Results: The nitrite and nitrate of serum decreased when progesterone injected, this effect blocked with l-arginine injection ,but nitrite and nitrate increased when estradiol administrated, this effect inhibited with l-name,The injection of both hormones did not significant effect on nitrite and nitrate level of serumes.

  Conclusion: These data suggest, ovarian steroid hormones regulates nitric oxide production and some effect of sex steroid hormones on target tissue may be mediated from nitric oxide system.

Keywords: Sex Steroied Hormones, Nitric Oxide , Nitrite-Nitrate


  Correspondng auther,tell: (281)2557048

Journal of Rafsanjan University of Medical Sciences and Health Services, 2002, 2(2):
Full-Text [PDF 258 kb]   (2462 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2005/12/8 | Published: 2003/09/15

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