Volume 24, Issue 9 (12-2025)
JRUMS 2025, 24(9): 821-834 |
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Ethics code: IR.RUMS.REC.1397.035
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Derakhshan R, Doost Mohammadi F. Short-Term Outcomes and Complications of Transcatheter Patent Ductus Arteriosus Closure in Four Pediatric Cardiology Centers in Iran (2011–2024): A Descriptive Study. JRUMS 2025; 24 (9) :821-834
URL: http://journal.rums.ac.ir/article-1-7771-en.html
URL: http://journal.rums.ac.ir/article-1-7771-en.html
School of Medicine, Kerman University of Medical Sciences
Abstract: (29 Views)
Background and Objectives: Patent ductus arteriosus (PDA) is one of the most common congenital heart defects, which, if untreated, may lead to cardiac and pulmonary complications. Transcatheter closure, as a minimally invasive and safe method, is considered a suitable alternative to surgery. This study aimed to determine the short-term outcomes of this method in four pediatric cardiac centers in Iran.
Materials and Methods: This descriptive cross-sectional study included 150 infants and children (aged 12 days to 3 years) who underwent transcatheter closure of a patent ductus arteriosus at four pediatric cardiac centers from 2011 to 2024. The collected data included demographic characteristics, echocardiographic and hemodynamic indices, device stability, and short-term complications. Data analysis was performed using a logistic regression model.
Results: The mean age of patients was 1.32±0.99 years, and 41 patients (27.3%) were preterm infants weighing less than 2 kilograms. The procedural success rate was 98.7% (148 patients). Minor complications were observed in 12.7% of cases (19 patients). A significant improvement in hemodynamic indices was reported post-procedure (p<0.001), but left ventricular function showed a non-significant increase (p=0.090). None of the factors, including age, weight, device type, and need for ventilation, showed a significant association with the occurrence of complications (p>0.05).
Conclusion: The findings of the current study suggest that transcatheter closure of patent ductus arteriosus in children and infants is a procedure associated with minimal short-term complications and leads to improvements in hemodynamic indices. However, careful monitoring of preterm infants is recommended to optimize outcomes.
Keywords: Patent ductus arteriosus, Transcatheter closure, Congenital heart defect, Preterm infants, Hemodynamic indices, Iran
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical considerations: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study (IR.RUMS.REC.1397.035).
Authors’ contributions:
- Conceptualization: Reza Derakhshan
- Methodology: Fatemeh Doost Mohammadi
- Data collection: Reza Derakhshan, Fatemeh Doost Mohammadi
- Formal analysis: Fatemeh Doost Mohammadi
- Supervision: Reza Derakhshan
- Project administration: Reza Derakhshan
- Writing – original draft: Fatemeh Doost Mohammadi, Reza Derakhshan
- Writing – review & editing: Fatemeh Doost Mohammadi
Materials and Methods: This descriptive cross-sectional study included 150 infants and children (aged 12 days to 3 years) who underwent transcatheter closure of a patent ductus arteriosus at four pediatric cardiac centers from 2011 to 2024. The collected data included demographic characteristics, echocardiographic and hemodynamic indices, device stability, and short-term complications. Data analysis was performed using a logistic regression model.
Results: The mean age of patients was 1.32±0.99 years, and 41 patients (27.3%) were preterm infants weighing less than 2 kilograms. The procedural success rate was 98.7% (148 patients). Minor complications were observed in 12.7% of cases (19 patients). A significant improvement in hemodynamic indices was reported post-procedure (p<0.001), but left ventricular function showed a non-significant increase (p=0.090). None of the factors, including age, weight, device type, and need for ventilation, showed a significant association with the occurrence of complications (p>0.05).
Conclusion: The findings of the current study suggest that transcatheter closure of patent ductus arteriosus in children and infants is a procedure associated with minimal short-term complications and leads to improvements in hemodynamic indices. However, careful monitoring of preterm infants is recommended to optimize outcomes.
Keywords: Patent ductus arteriosus, Transcatheter closure, Congenital heart defect, Preterm infants, Hemodynamic indices, Iran
Funding: This study did not have any funds.
Conflict of interest: None declared.
Ethical considerations: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study (IR.RUMS.REC.1397.035).
Authors’ contributions:
- Conceptualization: Reza Derakhshan
- Methodology: Fatemeh Doost Mohammadi
- Data collection: Reza Derakhshan, Fatemeh Doost Mohammadi
- Formal analysis: Fatemeh Doost Mohammadi
- Supervision: Reza Derakhshan
- Project administration: Reza Derakhshan
- Writing – original draft: Fatemeh Doost Mohammadi, Reza Derakhshan
- Writing – review & editing: Fatemeh Doost Mohammadi
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Citation: Doost Mohammadi F, Derakhshan R. Short-Term Outcomes and Complications of Transcatheter Patent Ductus Arteriosus Closure in Four Pediatric Cardiology Centers in Iran (2011–2024): A Descriptive Study. J Rafsanjan Univ Med Sci 2025; 24 (9): 821-34. [Farsi]
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Keywords: Patent ductus arteriosus, Transcatheter closure, Congenital heart defect, Preterm infants, Hemodynamic indices, Iran
Type of Study: Research |
Subject:
cardiology
Received: 2025/06/30 | Accepted: 2025/11/23 | Published: 2025/12/19
Received: 2025/06/30 | Accepted: 2025/11/23 | Published: 2025/12/19
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