Volume 2, Number 1 (6-2003)                   JRUMS 2003, 2(1): 45-51 | Back to browse issues page


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Taherian A, Vafaie A, Rashidy pour A, Miladi gorgi H, Jarrahi M. Effect of Dexamethasone and Swimming Stress on Pain Modulation by Two Pain Assessment Methods in Albino Mice. JRUMS. 2003; 2 (1) :45-51
URL: http://journal.rums.ac.ir/article-1-58-en.html

مربي، عضو هيئت علمي
Abstract:   (12375 Views)

  Effect of Dexamethasone and Swimming Stress on Pain Modulation by Two Pain Assessment Methods in Albino Mice.

 

  A.A.Taherian1*, A.A. Vafaie2, A. Rashidy pour3, H. Miladi gorgi1, M. Jarrahi 1

 

  1-Academic Member, Deptartment of Physiology, University of Medical Sciences, Semnan, Iran

  2-Assistant Professor, Deptartment of Physiology, University of Medical Sciences, Semnan, Iran

  3-Associate professor, Deptartment of Physiology, University of Medical Sciences, Semnan, Iran

 

  Background: Previous findings have indicated that glucocorticoids may have an important role in the modulation of acute and chronic pain. The present work investigated the effect of acute stress and dexamethasone (as a glucocorticoids, agonist) on acute pain by two assessment methods (Hot Plate and Tail Flick) in Albino mice.

  Materials and Methods: In this experiment 60 Albino mice (25-30g) were divided into 6 groups. The animals were given 2 days to adapt to the experiment,s condition.Tail flick and Hot plate tests were used for evaluation of analgesic effect of the drug and stress. Dexamethasone( 0.5, 1 and 2 mg/kg) as an agonist of glucocorticoids and saline were
injected 3 minutes before the test or before the animals received stress by swiming in cold water (18 - 22ºc).The sign of pain was movement of tail in tail flick and grooming in hot plate.

  Results : The findings of this study indicated that the stress of cold waterand Dexamethasone (0.5 and 1mg/kg) have reduced the animals, responses to pain stimulants in both methods significantly (p<0.01). The effect of 2mg/kg Dexamethasone was not significant whereas the effects of stress alone were more than Dexamethasone.

  Conclusion: The present data showed that stress and the activation of glucocorticoids, receptors reduce the acute pain. To undrestand the analgesic mechanisms of stress and glucocorticoids, further studies remain to be accomplished.

 

  Keywords: Glucocorticoid receptors, Pain , Stress ,Tail flick, Hot plate , Albino mice

 

  *Corresponding author, tel: (0231) 3332080-82

Journal of Rafsanjan University of Medical Sciences and Health Services, 2002, 2(1) : 45- 51
Full-Text [PDF 281 kb]   (1581 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2005/12/8

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