Journal of Rafsanjan University of Medical Sciences
Volume 25, Issue 2 (7-2026)
JRUMS 2026, 25(2): 201-206 |
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Mobini M, Nazari Y, Salim Abadi Y. The Challenge of Emergence of Insecticide Resistance in Aedes Mosquito
(Dengue Fever Vector): A Letter to the Editor. JRUMS 2026; 25 (2) :201-206
URL: http://journal.rums.ac.ir/article-1-7984-en.html
URL: http://journal.rums.ac.ir/article-1-7984-en.html
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The Challenge of Emergence of Insecticide Resistance in Aedes Mosquito
(Dengue Fever Vector): A Letter to the Editor
Mohammad Mobini[1], Yasin Nazari[2], Yaser Salim Abadi[3]
Received: 04/04/26 Sent for Revision: 19/04/26 Received Revised Manuscript: 16/05/26 Accepted: 17/05/26
Dengue fever is an arboviral disease transmitted to humans by Aedes mosquitoes, causing diseases with varying severities. Following the establishment of Aedes mosquitoes in southern regions and an increase in dengue cases in the country, there is an urgent need for control measures against the disease vectors. The emergence of insecticide resistance in this species could pose a challenge, thus requiring more effective strategies in the vector control program. Moreover, continuous monitoring of resistance should also be included in the planning of vector control programs to enable precise, scientific implementation of intervention strategies.
Keywords: Dengue Fever, Aedes, Insecticides
Funding: No organization supported this study fnancially.
Conflict of interest: None declared.
Ethical considerations: Not applicable.
Authors’ contributions:
- Conceptualization: Yaser Salim Abadi, Mohammad Mobini
-Methodology: Mohammad Mobini, Yasin Nazari, Yaser Salim Abadi
- Data collection: Mohammad Mobini, Yasin Nazari
- Formal analysis: Not applicable
- Supervision: Yaser Salim Abadi
- Project administration: Mohammad Mobini
- Writing – original draft: Mohammad Mobini, Yasin Nazari, Yaser Salim Abadi
- Writing – review & editing: Mohammad Mobini, Yaser Salim Abadi
(Dengue Fever Vector): A Letter to the Editor
Mohammad Mobini[1], Yasin Nazari[2], Yaser Salim Abadi[3]
Received: 04/04/26 Sent for Revision: 19/04/26 Received Revised Manuscript: 16/05/26 Accepted: 17/05/26
Dengue fever is an arboviral disease transmitted to humans by Aedes mosquitoes, causing diseases with varying severities. Following the establishment of Aedes mosquitoes in southern regions and an increase in dengue cases in the country, there is an urgent need for control measures against the disease vectors. The emergence of insecticide resistance in this species could pose a challenge, thus requiring more effective strategies in the vector control program. Moreover, continuous monitoring of resistance should also be included in the planning of vector control programs to enable precise, scientific implementation of intervention strategies.
Keywords: Dengue Fever, Aedes, Insecticides
Funding: No organization supported this study fnancially.
Conflict of interest: None declared.
Ethical considerations: Not applicable.
Authors’ contributions:
- Conceptualization: Yaser Salim Abadi, Mohammad Mobini
-Methodology: Mohammad Mobini, Yasin Nazari, Yaser Salim Abadi
- Data collection: Mohammad Mobini, Yasin Nazari
- Formal analysis: Not applicable
- Supervision: Yaser Salim Abadi
- Project administration: Mohammad Mobini
- Writing – original draft: Mohammad Mobini, Yasin Nazari, Yaser Salim Abadi
- Writing – review & editing: Mohammad Mobini, Yaser Salim Abadi
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Citation: Mobini M, Nazari Y, Salim Abadi Y. The Challenge of Emergence of Insecticides Resistance in Aedes Mosquito (Dengue Fever Vector): A Letter to the Editor. J Rafsanjan Univ Med Sci 2026; 25 (2): 201-6. doi: 10.66224/jrums.25.2.201. [Farsi].
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[1]- Dept. of Environmental Health Engineering, School of Health, Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
[2]- Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
[3]- Dept. of Health Education and Health Promotion, School of Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
ORCID: 0000-0003-2185-3355
(Corresponding Author) Tel: (034) 31315242, E-mail: y.salimabadi@rums.ac.ir
ORCID: 0000-0003-2185-3355
(Corresponding Author) Tel: (034) 31315242, E-mail: y.salimabadi@rums.ac.ir
Type of Study: Research |
Subject:
Environmental Health
Received: 2026/05/11 | Accepted: 2026/06/8 | Published: 2026/07/28
Received: 2026/05/11 | Accepted: 2026/06/8 | Published: 2026/07/28
References
1. Pourzangiabadi M, Najafi H, Fallah A, Goudarzi A, Pouladi I. Dengue virus: Etiology, epidemiology, pathobiology, and developments in diagnosis and control–A comprehensive review. Infection, Genetics and Evolution 2025; 1: 127: 105710.
2. Dorzaban H, Soltani A, Alipour H, Hatami J, Jaberhashemi SA, Shahriari-Namadi M, et al. Mosquito surveillance and the first record of morphological and molecular-based identification of invasive species Aedes (Stegomyia) aegypti (Diptera: Culicidae), southern Iran. Experimental Parasitology 2022; 1: 236: 108235.
3. Azari-Hamidian S, Norouzi B, Maleki H, Rezvani SM, Pourgholami M, Oshaghi MA. First record of a medically important vector, the Asian tiger mosquito Aedes albopictus (Skuse, 1895) (Diptera: Culicidae), using morphological and molecular data in northern Iran. Journal of Insect Biodiversity and Systematics 2024; 20: 10(4): 953-63.
4. Asgarian TS, Enayati A, Moosa-Kazemi SH, Zaim M, Jaberhashemi SA, Saeidi Z, et al. Organophosphate and pyrethroid resistance status of invasive Aedes aegypti (Diptera: Culicidae) from Iran. Journal of Arthropod-Borne Diseases 2024; 31: 18(4): 296.
5. Jamal MK, Sanaei B, Naderi M, Past V, Abadi SH, Khazaei R, et al. Investigating the recent outbreak of dengue fever in Iran: a systematic review. The Egyptian Journal of Internal Medicine 2025; 37(1): 1-21.
6. Sanei-Dehkordi A, Paksa A, Gorouhi MA, Poudat A, Rashid G, Akbarzadeh Z,et al. High Resistance to DDT and Common Pyrethroid Insecticides in Aedes aegypti, From Iran. Hormozgan Medical Journal 2024; 28(2): 123-8.
7. Asgarian TS, Enayati A, Moosa-Kazemi SH, Zaim M, Jaberhashemi SA, Saeidi Z, et al. Organophosphate and pyrethroid resistance status of invasive Aedes aegypti (Diptera: Culicidae) from Iran. Journal of Arthropod-Borne Diseases 2024; 18(4): 296.
8. Asgarian TS, Vatandoost H, Hanafi-Bojd AA, Nikpoor F. Worldwide status of insecticide resistance of Aedes aegypti and Ae. albopictus, vectors of arboviruses of chikungunya, dengue, zika and yellow fever. Journal of Arthropod-Borne Diseases 2023; 31; 17(1): 1-27.
9. Mohsin M, Naz SI, Khan I, Jabeen A, Bilal H, Ahmad R, et al. Susceptibility status of Aedes aegypti and Aedes albopictus against insecticides at eastern Punjab, Pakistan. International Journal of Mosquito Research 2016; 3(5): 41-6.
10. Al Nazawi AM, Aqili J, Alzahrani M, McCall PJ, Weetman D. Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia. Parasite and Vectors 2017; 10(1): 161.
11. Paksa A, Azizi K, Yousefi S, Dabaghmanesh S, Shahabi S, Sanei-Dehkordi A. First report on the molecular phylogenetics and population genetics of Aedes aegypti in Iran. Parasites & Vectors 2024; 17(1): 49.
12. Al Nazawi AM, Aqili J, Alzahrani M, McCall PJ, Weetman D. Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia. Parasites & vectors 2017; 10(1): 161.
13. Tanzila G, Rasheed SB, Khan NH, Kausar A, Jahan F, Wahid S. Insecticide susceptibility and detection of kdr-gene mutations in Aedes aegypti of Peshawar, Pakistan. Acta Tropica 2023; 1: 242: 106919.
14. Enayati A, Valadan R, Bagherzadeh M, Cheraghpour M, Nikookar SH, Fazeli-Dinan M, et al. Kdr genotyping and the first report of V410L and V1016I kdr mutations in voltage-gated sodium channel gene in Aedes aegypti (Diptera: Culicidae) from Iran. Parasites & Vectors. 2024; 17(1): 34.1-15.
15. World Health Organization (2023) Report on insecticide resistance in Aedes mosquitoes (Aedes aegypti, Ae. albopictus, Ae. vittatus) in WHO South-East Asia Region countries. Available at: https://www.who.int/publications/i/item/sea-cd-334.
16. Asgarian TS, Moosa-Kazemi SH, Sedaghat MM. Evaluating the larvicidal effect of Bacillus Thuringiensis MH-14 on Aedes aegypti larvae under laboratory and semi-field conditions in Southern Iran. Scientific Reports 2025; 15(1): 43052.
17. Roiz D, Wilson AL, Scott TW, Fonseca DM, Jourdain F, Müller P, et al. Integrated Aedes management for the control of Aedes-borne diseases. PLoS neglected tropical diseases 2018; 12(12): e0006845.
18. Pourzangiabadi M, Najafi H, Fallah A, Goudarzi A, Pouladi I. Dengue virus: Etiology, epidemiology, pathobiology, and developments in diagnosis and control–A comprehensive review. Infection, Genetics and Evolution 2025; 1: 127: 105710.
19. Dorzaban H, Soltani A, Alipour H, Hatami J, Jaberhashemi SA, Shahriari-Namadi M, et al. Mosquito surveillance and the first record of morphological and molecular-based identification of invasive species Aedes (Stegomyia) aegypti (Diptera: Culicidae), southern Iran. Experimental Parasitology 2022; 1: 236: 108235.
20. Azari-Hamidian S, Norouzi B, Maleki H, Rezvani SM, Pourgholami M, Oshaghi MA. First record of a medically important vector, the Asian tiger mosquito Aedes albopictus (Skuse, 1895) (Diptera: Culicidae), using morphological and molecular data in northern Iran. Journal of Insect Biodiversity and Systematics 2024; 20: 10(4): 953-63.
21. Asgarian TS, Enayati A, Moosa-Kazemi SH, Zaim M, Jaberhashemi SA, Saeidi Z, et al. Organophosphate and pyrethroid resistance status of invasive Aedes aegypti (Diptera: Culicidae) from Iran. Journal of Arthropod-Borne Diseases 2024; 31: 18(4): 296.
22. Jamal MK, Sanaei B, Naderi M, Past V, Abadi SH, Khazaei R, et al. Investigating the recent outbreak of dengue fever in Iran: a systematic review. The Egyptian Journal of Internal Medicine 2025; 37(1): 1-21.
23. Sanei-Dehkordi A, Paksa A, Gorouhi MA, Poudat A, Rashid G, Akbarzadeh Z,et al. High Resistance to DDT and Common Pyrethroid Insecticides in Aedes aegypti, From Iran. Hormozgan Medical Journal 2024; 28(2): 123-8.
24. Asgarian TS, Enayati A, Moosa-Kazemi SH, Zaim M, Jaberhashemi SA, Saeidi Z, et al. Organophosphate and pyrethroid resistance status of invasive Aedes aegypti (Diptera: Culicidae) from Iran. Journal of Arthropod-Borne Diseases 2024; 18(4): 296.
25. Asgarian TS, Vatandoost H, Hanafi-Bojd AA, Nikpoor F. Worldwide status of insecticide resistance of Aedes aegypti and Ae. albopictus, vectors of arboviruses of chikungunya, dengue, zika and yellow fever. Journal of Arthropod-Borne Diseases 2023; 31; 17(1): 1-27.
26. Mohsin M, Naz SI, Khan I, Jabeen A, Bilal H, Ahmad R, et al. Susceptibility status of Aedes aegypti and Aedes albopictus against insecticides at eastern Punjab, Pakistan. International Journal of Mosquito Research 2016; 3(5): 41-6.
27. Al Nazawi AM, Aqili J, Alzahrani M, McCall PJ, Weetman D. Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia. Parasite and Vectors 2017; 10(1): 161.
28. Paksa A, Azizi K, Yousefi S, Dabaghmanesh S, Shahabi S, Sanei-Dehkordi A. First report on the molecular phylogenetics and population genetics of Aedes aegypti in Iran. Parasites & Vectors 2024; 17(1): 49.
29. Al Nazawi AM, Aqili J, Alzahrani M, McCall PJ, Weetman D. Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia. Parasites & vectors 2017; 10(1): 161.
30. Tanzila G, Rasheed SB, Khan NH, Kausar A, Jahan F, Wahid S. Insecticide susceptibility and detection of kdr-gene mutations in Aedes aegypti of Peshawar, Pakistan. Acta Tropica 2023; 1: 242: 106919.
31. Enayati A, Valadan R, Bagherzadeh M, Cheraghpour M, Nikookar SH, Fazeli-Dinan M, et al. Kdr genotyping and the first report of V410L and V1016I kdr mutations in voltage-gated sodium channel gene in Aedes aegypti (Diptera: Culicidae) from Iran. Parasites & Vectors. 2024; 17(1): 34.1-15.
32. World Health Organization (2023) Report on insecticide resistance in Aedes mosquitoes (Aedes aegypti, Ae. albopictus, Ae. vittatus) in WHO South-East Asia Region countries. Available at: https://www.who.int/publications/i/item/sea-cd-334.
33. Asgarian TS, Moosa-Kazemi SH, Sedaghat MM. Evaluating the larvicidal effect of Bacillus Thuringiensis MH-14 on Aedes aegypti larvae under laboratory and semi-field conditions in Southern Iran. Scientific Reports 2025; 15(1): 43052.
34. Roiz D, Wilson AL, Scott TW, Fonseca DM, Jourdain F, Müller P, et al. Integrated Aedes management for the control of Aedes-borne diseases. PLoS neglected tropical diseases 2018; 12(12): e0006845.
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