BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
URL: http://journal.rums.ac.ir/article-1-1834-en.html
Background and Objective: Nonalcoholic fatty liver disease is one of the most common causes of
chronic liver injury throughout the world. In this study, the preventive
effects of green tea extract on fatty liver disease induced by high fat diet is
assessed in the rats.
Materials
and Methods: In this experimental study, male Wistar rats were randomly divided to: Healthy control, Feeding with
high fat diet, Feeding with high fat diet plus Clofibrate treatment and Feeding with high fat diet plus Green tea extract
treatment groups. The rats treated with either high fat diet for induction of
hepatic steatosis and high fat diet plus Clofibrate or Green tea extract for
prevention of liver steatosis, at a period of 6 weeks. At the end of
experiment, Serum lipid profile, serum biomarkers of liver tissue injury and
hepatic antioxidant activity were statistically compared among the groups using
one-way ANOVA and Tukey post-tests. The biochemical findings were matched with
histopathological verifications.
Results: In the
rats fed with high-fat diet hypertriglyceridemia and hypercholesterolemia were
created. In these animals,
increased serum levels of hepatocellular enzymes and significant reduction in
antioxidants as well as elevated hepatic lipid peroxidation index were
encountered (p=0.001). Extract treatment significantly reduced elevated markers
of liver tissue injury (p=0.023) and malondialdehyde (p=0.032),
and brought back the liver antioxidants (p=0.028) and the over accumulation of
serum lipids towards normal. Histopathology of the liver confirmed the changes
induced by high fat diet and the preventive effect of green tea extract.
Conclusion: Preventive
effect of green tea on fatty liver disease in the rats fed with high fat diet
is related to its antioxidant properties.
Key
words: High fat fed diet, Green tea, Antioxidants, Hepatic steatosis
Funding: This research was funded by Tabriz Branch, Islamic Azad
University.
Conflict of interest: None declared.
Ethical approval: The
Ethics Committee of Tabriz Branch, Islamic Azad University approved the study.
How
to cite this article:
Karami Robati A, Ayatollahi Mousavi SA, Hadizadeh S. Study of Nosocomial Fungal
infections acquired from Kerman education hospitals. J Rafsanjan Univ Med
Sci 2014 13(2): 125-40
[Farsi]
Received: 2013/07/26 | Accepted: 2014/06/11 | Published: 2014/06/11
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
