Journal of Rafsanjan University of Medical Sciences

  Relationship Between Hematological Factors and Metabolic Syndrome in an Iranian Population Isfahan Healthy Heart Program

  M. Sadeghi MD [1] , HR. Roohafza MD [2] , SH. Shirani MD [3] , AM. Baghaei GP [4] , I. Golshadi BSc [5] ,
P. Aghdak GP [6]

  Recived: 26/05/2005 Revised: 28/06/2006 Accepted: 17/07/2006

  Background and Objective: Metabolic syndrome is considered as one of the risk factor for Cardio Vascular Disease (CVD). Correlation between this syndrom and white and red blood cell counts is unknown whereas the relationship between insulin resistance and hamatologic factors is indicated in some published articles. The purpose of this study was to assess the correlation between hematologic parameters and metabolic syndrome.

  Material and Methods: In a descriptive study 11974 over 19 years old participants in Isfahan, Najaf-Abad and Arak in rural and urban areas was evaluated as part of Isfahan Healthy Heart Program (IHHP) study . At first these participants' demographic data (age, sex, past history and drug consumption) were collected then trained physicians measured their blood pressure and waist circumference. Blood pressure in two separate occasions was recorded and mean of these measures was used in this study. In all participants, laboratory examinations (RBC, WBC, HDL-C, FBS, TG) were done after a 12 hour fasting. Participants were evaluated for metabolic syndrome according to ATP-III criteria. Data were entered in to SPSS-11 and analyzed by t-test and Spearmen correlation.

  Results: Overall 6132(51%) females and 5842(49%) males with mean age of 35.6±3.8 and 35.9±32 year were studied respectively. The prevalence of metabolic syndrome in male and female participants were 10.6% and 35% respectively and 23/1% in overall. WBC and RBC counts were higher in patients with metabolic syndrome compared to those of normal subjects. Correlation between metabolic syndrome and RBC and WBC counts was significant excluding the case of hypertension. The most powerful correlation was obsereved between count RBC and HDL-C (r: -0.245, p<0.001), WBC and TG (r: 0.195, p<0.001).

  Conclusion: We observed increased RBC and WBC counts in patients with metabolic syndrome. In this regard a widespread study may help us use these hematologic parameters even in normal values as indicators for evaluation of high risk patients.

 �

  Key words: Metabolic Syndrome, White Blood Cell, Red Blood Cell

  [1] - Assistant Dept. of Cardiology, Cardiovascular Research Center University of Medical Sciences, Isfahan

 �(Corresponding Author) Tel:(0311)3359696, Fax: (0311) 3373435, E-mail: m_sadeghi@crc.mui.ac.ir

  [2] - Assistant Prof. Dept of Psychiatry, University of Medical Sciences, Isfahan

  [3] - Assistant Professor of Cardiology, Cardiovascular Research Center, Isfahan

  [4] - General Physition, Research Directive, Cardiovascular Research Center, Isfahan

  [5] - Instructor in Laboratory, University of Medical Sciences, Isfahan

  [6] - General Physition , Health Center, Isfahan