Volume 21, Issue 8 (11-2022)
JRUMS 2022, 21(8): 869-884 |
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Ethics code: IR.IAU.URMIA.REC.1401.005
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Nankali A, Abbasi-Maleki2,3 S, Najafi G. Antidepressant Activity of Tanacetum Balsamita Essential Oil on Some Experimental Models of Depression in Mice. JRUMS 2022; 21 (8) :869-884
URL: http://journal.rums.ac.ir/article-1-6496-en.html
URL: http://journal.rums.ac.ir/article-1-6496-en.html
Kermanshah University of Medical Science
Abstract: (810 Views)
Background and Objectives: Oxidative stress plays an important role in the pathophysiology of many diseases, including depression. On the other hand, previous studies have reported the antioxidant effect of Tanacetum balsamita. The aim of the present study is to investigate the antidepressant effect of Tanacetum balsamita essential oil (TBEO) in animal models of depression.
Materials and Methods: In this experimental study, 84 mice were randomly divided into 14 groups of 6 and intraperitoneally received vehicle (10 ml/kg), fluoxetine (20 mg/kg), imipramine (30 mg/kg), and TBEO (12.5, 50,100, and 200mg/kg). To evaluate the antidepressant effect, the forced swimming test (FST) and tail suspension test (TST) were used. The animal locomotion was also assessed by open-field test (OFT). Data were analyzed using one-way analysis of variance followed by the Newman-Keuls post hoc test.
Results: Doses of 50 to 100 mg/kg of essential oil in both FST and TST caused a significant reduction in the duration of immobility (p<0.001). In addition, doses of 50,100 and 200 mg/kg of TBEO significantly increased swimming time (p<0.001). But, climbing time was not significantly increased by all doses of the essential oil (p>0.05). Also, none of the essential oil doses caused a significant change in the number of crossing and rearing’s in the OFT (p>0.05).
Conclusion: Tanacetum balsamita essential oil has an anti-depressant effect in mice. Nevertheless, more studies are needed to determine its mechanism of action.
Key words: Tanacetum balsamita, Antidepressant, Forced swimming test, Tail suspension test, Mice
Funding: This study was funded by Islamic Azad University, Urmia Branch, Iran.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Islamic Azad University of Urmia Branch approved the study (IR.IAU.URMIA.REC.1399.024).
How to cite this article: Nankali Amir-khosro, Abbasi-Maleki Saeid, Najafi Ghader. Antidepressant Activity of Tanacetum Balsamita Essential Oil on Some Experimental Models of Depression in Mice. J Rafsanjan Univ Med Sci 2022; 21 (8): 869-84. [Farsi]
Materials and Methods: In this experimental study, 84 mice were randomly divided into 14 groups of 6 and intraperitoneally received vehicle (10 ml/kg), fluoxetine (20 mg/kg), imipramine (30 mg/kg), and TBEO (12.5, 50,100, and 200mg/kg). To evaluate the antidepressant effect, the forced swimming test (FST) and tail suspension test (TST) were used. The animal locomotion was also assessed by open-field test (OFT). Data were analyzed using one-way analysis of variance followed by the Newman-Keuls post hoc test.
Results: Doses of 50 to 100 mg/kg of essential oil in both FST and TST caused a significant reduction in the duration of immobility (p<0.001). In addition, doses of 50,100 and 200 mg/kg of TBEO significantly increased swimming time (p<0.001). But, climbing time was not significantly increased by all doses of the essential oil (p>0.05). Also, none of the essential oil doses caused a significant change in the number of crossing and rearing’s in the OFT (p>0.05).
Conclusion: Tanacetum balsamita essential oil has an anti-depressant effect in mice. Nevertheless, more studies are needed to determine its mechanism of action.
Key words: Tanacetum balsamita, Antidepressant, Forced swimming test, Tail suspension test, Mice
Funding: This study was funded by Islamic Azad University, Urmia Branch, Iran.
Conflict of interest: None declared.
Ethical approval: The Ethics Committee of Islamic Azad University of Urmia Branch approved the study (IR.IAU.URMIA.REC.1399.024).
How to cite this article: Nankali Amir-khosro, Abbasi-Maleki Saeid, Najafi Ghader. Antidepressant Activity of Tanacetum Balsamita Essential Oil on Some Experimental Models of Depression in Mice. J Rafsanjan Univ Med Sci 2022; 21 (8): 869-84. [Farsi]
Type of Study: Research |
Subject:
Pharmacology
Received: 2022/04/12 | Accepted: 2022/11/5 | Published: 2022/11/19
Received: 2022/04/12 | Accepted: 2022/11/5 | Published: 2022/11/19
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