Journal of Rafsanjan University of Medical Sciences

  The Survey of Aloe Vera Aqueous Extract and Glibenclamid Interaction on Blood Glucose, LFT and Lipids Diabetic Induced Male Rats By Streptozotocin

  M. Jadidoleslami [1] , M. Abbasnejad [2] , M.R. Shahraki [3]

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  Received: 02/05/07 Sent for Revision: 17/06/07 Received Revised Manuscript: 04/07/10 Accepted: 19/07/10

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  Background and Objectives: Aloe vera is native to North Africa, and is also cultivated in Turkey. Aloe has long been used all over the world for its various medicinal properties. The aim of this study was to measure the interaction effect of Aloe vera and glibenclamid on blood glucose, LFT and lipid metabolism in streptozotocine-induced diabetic male rats.

  Materials and Methods: This experimental study was carried out on 40 wistar Albino male rats in Zahedan University of Medical Sciences. Animals were divided into five groups, one as control (intact) , and the others as experimental groups. Rats in the experimental groups were made diabetic by streptozotocin injection (65mg/kg-IP). The diabetic groups, except one (diabetic control), received 400 mg/kg aloe vera extract, 5mg/kg glibenclamid and 400 mg/kg Aloe vera extract with 5 mg/kg glibenclamid daily for 4 weeks by gavages respectively. At the end of experiement fasting blood samples were collected from all groups.

  Results: The results showed that FBS, TG, Ch, AST, ALT levels in the experimental groups were significantly decreased in comparison with those in the control group (p<0.05) . There was no significant difference on HDL level. In addition, Alk.P level in glibenclamid alone and glibenclamid + Aloe vera groups were significantly increased in comparison with the control group (p<0.05) .

  Conclusion: The results of this research indicate that interaction of Aloe vera aqueous extract and glibenclamid decrease blood glucose, TG, Ch, LDL, AST and ALT levels . However, the effect of Aloe vera extract in combination was not greater than the effect of Aloe vera extract alone. These findings may be due to the effects of Aloe vera and glibenclamid on glucose metabolism. Further research is suggested to study the exact mechanism of them in diabetic rats.

  Key word: Aloe Vera, Lipoprotein, Glibenclamid, Diabetes, Streptozotocine

  Funding: This research was funded by Zahedan University of Medical Sciences.

  Conflict of Interest: None declared.

  Ethical approval: The Ethics Committee of Zahedan University of Medical Sciences approved the study.

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  [1] - MSc, Dept. of Biology, Faculty of Science, Shahid Bahonar University, Kerman, Iran

  [2] - Associate Prof., Dept. of Biology , Shahid Bahonar University, Kerman, Iran

  (Corresponding Author) Tel: (0341) 3222032, Fax: (0341) 3222032, E-mail: mabbas@mail.uk.ac.ir

  [3] - Assistant Prof., Dept. of Physiology, Faculty of Medicine, University of Medical Sciences, Zahedan, Iran