Volume 13, Issue 4 (10-2014)                   JRUMS 2014, 13(4): 371-382 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salimnejad R, Jalali M, Nikravesh M, Fazel A. Effect of Garlic Aqueous Extract on Markers of Oxidative Stress in Diabetic Rats Testes. JRUMS 2014; 13 (4) :371-382
URL: http://journal.rums.ac.ir/article-1-2037-en.html
Mashhad University of Medical sciences
Abstract:   (8003 Views)

Background and Objective: Diabetes mellitus is one of the most prevalent metabolic diseases and causes testicular damage by rising oxidative stress. Using antioxidants reduces oxidative stress and the amount of testicular damage. In this study, the effect of garlic extract on markers of oxidative stress in diabetic rats testes has been studied.

Materials and Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups: Control, Diabetic and Diabetic with garlic extract. Control and diabetic groups received distilled water (1ml/100g BW) and diabetic with garlic extract received garlic extract (1ml/100g BW,equivalent to 400 mg/100 g BW) for 6 weeks. Diabete was induced by a single intraperitoneal injection of streptozotocin at a dosage of 60 mg/kg BW. After 6 weeks, the right testis removed and activity of oxidative stress enzymes including malondialdehyde (MDA), catalase (CAT) and superoxide dismutase (SOD) were studied.

Results: Treatment of diabetic rats with garlic extract significantly reduced blood glucose levels (p<0.001). Also during diabete, the level of MDA enzymes activity was increased and the level of SOD and CAT enzymes activity decreased in the testes. Treatment with the garlic extract significantly improved these parameters (p<0.001).

Conclusion: The results of this study confirm the antioxidant role of garlic extract on improving the testicular damage caused by diabete.

Key words: Oxidative Stress, Diabetes Mellitus, Garlic Extract, Testis


Funding: This research was funded by Mashhad University of Medical sciences.

Conflict of Interest: None declared.

Ethical approval: The Ethics Committee of Mashhad University of Medical Sciences approved the study.


How to cite this article: Salimnejad R, Jalali M, Nikravesh MR, Fazel AR. Effect of Garlic Aqueous Extract on Markers of Oxidative Stress in Diabetic Rats Testes. J RafsanjanUniv Med Sci 2014 13(4): 371-82. [Farsi]


Full-Text [PDF 267 kb]   (3931 Downloads) |   |   Full-Text (HTML)  (1705 Views)  
Type of Study: Research | Subject: Biochemistry
Received: 2014/01/11 | Accepted: 2014/10/28 | Published: 2014/10/28

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Rafsanjan University of Medical Sciences

Designed & Developed by : Yektaweb